Total views : 160

Predicting Arterial Stiffness from Physiological Characteristics of Photoplethysmography Signals Quantified Through Second Derivative

Affiliations

  • Anna University, Chennai – 600025, Tamil Nadu, India
  • School of Electronics Engineering, VIT University, Vandalur, Kelambakkam Road, Chennai – 600127, Tamil Nadu, India
  • Department of Electronics and Communication Engineering, St. Joseph’s College of Engineering, Old Mamallapuram Road, Semmencherry, Chennai – 600119, Tamil Nadu, India

Abstract


Objectives: Cardiovascular diseases arise mainly due to arterial stiffening leading to atherosclerosis and arteriosclerosis. Contour analysis of second Derivative Photoplethysmogram (SDPPG) reveals cardiovascular properties. In this paper, a novel SDPPG analysis algorithm is used for the assessment of arterial stiffness. Methods/Statistical Analysis: The proposed algorithm based on re-sampling technique is used for an accurate detection of significant points of interest (a, b and e wave) in SDPPG to evaluate desired parameters for the assessment of arterial stiffness. The parameters identified are PPL (PPG peak latency), PNL (PPG notch latency), PNRA (PPG notch relative amplitude), PTNL (peak to notch latency) and NI (Notch Index) and the correlation between these parameters are studied on the records obtained from the large-scale openly available database PhysioNet. Findings: The performance evaluation of the proposed SDPPG analysis algorithm is better than existing methods in terms of sensitivity and positive predictivity for a, b and e wave detection. Correlation analysis were examined for the PPG signals with low and varying amplitudes, regular and irregular heart rhythms and non-stationary signals that varies from healthy adults to unhealthy and aged patients. The positive linear correlation coefficient 'r' ranges from 0.7 to 0.9 for NI and PNL or PNL and PTNL, representing a significant relationship between them whereas PNL and PPL, NI and PTNL or NI and PPL, present a moderate correlation. However, a negative correlation with r = -0.66 is obtained for PNRA and PTNL. The parameters associated with dicrotic notch NI, PNL and PTNL considerably reflect the stiffness of the arteries, with smaller values of these parameters indicating stiffer arteries. Hence, the notch is the valuable characteristics of the PPG Waveform and plays a significant role in the diagnosis of arterial condition. Also, faithful association between arterial stiffness and Pulse Wave Velocity (PWV) can be acquired from PNRA and PNL, as they represent relative height of notch and position of notch with respect to time respectively, instead of Stiffness index (SI) and Reflection Index (RI) that relates stiffness of arteries. Application/Improvement: Although, the number of PPG records used for performance evaluation was self-effacing, a larger database is required to validate the findings of this study.

Keywords

Arterial Stiffness, Dicrotic Notch Detection, Digital Volume Pulse (DVP), Derivative of the Photoplethysmography Signal (SDPPG), Onsets, Second Systolic Peaks.

Full Text:

 |  (PDF views: 127)

References


  • Rajzer MW, Wojciechowska W, Klocek M, Palka I, Brzozowska-Kiszka M, Kawecka-Jaszcz K. Comparison of aortic pulse wave velocity measured by three techniques: Complior, sphygmoCor and Arteriograph. Journal of Hypertension. 2008; 26(10):2001-7. Available from: Crossref PMid:18806624
  • Sandrine C, Millasseaua M, James M, Takazawab RK, Philip J Chowienczyka. Contour analysis of the photoplethysmographic pulse measured at the finger. Journal of Hypertension. 2006; 24(8):1449-56. Available from: Crossref PMid:16877944
  • Elgendi M. On the analysis of fingertip Photoplethysmogram signals. Current Cardiology Reviews. 2012;
  • (1):14-25. Available from: Crossref PMid:22845812 PMCid:PMC3394104
  • Laurent S, Cockcroft J, Bortel VL, Boutouyrie P, Giannattasio C, Hayoz D. Expert consensus document on arterial stiffness: methodological issues and clinical applications. European Heart Journal. 2006; 27(1):2588-605. Available from: Crossref PMid:17000623
  • Kamal AA, Harness JB, Irving G, Mearns AJ. Computer Methods and Programs in Biomedicine.1989; 47(28):25769. Available from: Crossref
  • Blacher J, Asmar R, Djane S, London GM, Safar ME. Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients. Journal of Hypertension. 1999; 33:1111-17. Available from: Crossref HYP.33.5.1111
  • Bortolotto LA, Blacher J, Kondo T, Takazawa K, Safar ME. Assessment of vascular aging and atherosclerosis in hypertensive subjects: second derivative of photoplethysmogram versus pulse wave velocity. American Journal of Hypertension. 2000; 13(2):165-71. Available from: Crossref
  • Vimal Prabhu P, Sivaraman J, Sathish S, Vinurajkumar S, Manikandan K. Detection and Evaluation of Vascular Wall Elasticity using Photoplethysmography Signals in Sinus Rhythm Subjects. Indian Journal of Science and Technology. 2016 January; 9(2). Doi no: Crossref
  • Millasseau SC, Kelly RP, Ritter JM, Chowienczyk PJ. Determination of age-related increases in large artery stiffness by digital pulse contour analysis. Clinical Science. 2002; 103(3):371-77. Available from: Crossref PMid:12241535
  • Brumfield AM, Andrew ME. Digital pulse contour analysis: investigating age-dependent indices of arterial compliance. Physiology Measurement. 2005; 26(5):599-608. Available from: Crossref PMid:16088055
  • Pilt K, Ferenets R, Meigas K, Lindberg LG, Temitski K, Viigimaa M . New Photoplethysmographic Signal Analysis Algorithm for Arterial Stiffness Estimation. The Scientific World Journal. 2013; p. 9.
  • Shi P, Hu S, Zhu Y, Zheng J, Qiu Y, Tong S, P Cheang. Insight into the dicrotic notch in photoplethysmographic pulses from finger tip of young adults. Journal of Medical Engineering and Technology. 2009; 33(8):628-33. Available from: Crossref PMid:19848856
  • Mohanalakshmi S, Sivasubramanian A, Swarnalatha A. An adaptive delineator for photoplethysmography waveforms. Biomedizinische Technik/Biomedical Engineering 2015.
  • Bortel V LM, Boudier S HA, Safar ME. Hypertension: Pulse pressure, arterial stiffness, and drug treatment of hypertension. 2001; 38(4):914-21. Available from: Crossref PMid:11641309

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.