Total views : 1515
A Mathematical Approach to the Carbohydrate Catabolism in Ascaris lumbricoides
Metabolic pathways within a biological cell serve as a key for the various functions of the living organism. In this article, the authors have considered a mathematical study of the carbohydrate catabolism of the nematode, Ascaris lumbricoides. The technique involves setting up of a Stoichiometric matrix (S) for the biochemical reactions involved in the process and calculating biochemically meaningful basis vectors for the null space of S. In the present study, the stoichiometric matrix S is of order 26×40 for which fourteen column vectors are obtained as forming the "basis". It is found that twelve column vectors represent the reversible reactions involved in the metabolic pathway and two-column vectors represents stoichiometry of the network.
Ascaris lumbricoides, Carbohydrate Metabolism, Nematode, Mathematical Approach
- Barrett J (1984) The anaerobic end products of helminths. Parasitol. 88, 179-198.
- Barrett J (1994) Biochemistry of helminths. In: Helminthology. Chowdhury N & Tada I (Ed.), Springer- Verlag, NY, pp: 211-232.
- Bernhard O. Palsson (2006) Systems biology, properties of reconstructed network. Cambridge Univ. Press.
- Bryant C (1994) Ancient biochemistries and evolution of parasites. Int. J. Parasitol. 24 (8), 1089-1097.
- Buckingham L and Jeffrey C Evans (1994) Hazardous waste management and the environmental resources management group. Tata –McGraw Hill.
- Bueding E and Saz HJ (1968) Pyruvate kinase and phosphoenolpyruvate kinase activities of Ascaris muscle, Hymenolepis diminuta and Schistosoma mansoni. Comp. Biochem. Physiol. 24, 511-518.
- Christophe H Schilling and Bernard O. Palsson (1998) The underlying pathway structure of biochemical reaction networks. Proc. Natl. Acad. Sci. USA. 95, 4193-4198.
- Fairlamb AH (1989) Novel biochemical pathways in parasitic protozoa. Parasitol. 99, 93-112.
- Gilbert Strang (2006) Linear Algebra and its Application, Cengage learning.
- Komuniecki R and Tielens AGM (2003) Carbohydrate and energy metabolism in parasitic helminths. In: Molecular medical parasitology. Marr JJ, Nilsen TW &Komuniecki RW (Eds.), Acad. Press, Amsterdam. pp: 339-358.
- Mansour Tag E and Joan Mackinnon Mansour (2002) Chemotherapeutic targets in parasites: Contemporary Strategies. Cambridge Univ., Press.
- Saz HJ and Bueding E (1966) Relationships between anthelminthic effects and biochemical and physiological mechanisms. Pharmacol. Rev.18, 871-894.
- Suarez de Mata Z, Zarrant ME, Lizardo R and Saz HJ (1983) 2-methylacetoacetyl coenzyme A reductase from Ascaris muscle: purification and properties. Arch. Biochem. Biophys. 226 (1) 84-93.
- Takamiya S, Kita K, Wang H, Weinstein P, Hiraishi A, Oya H and Aoki T (1993) Developmental changes in the respiratory chain of Ascaris mitochondria. Biochim. Biopys. Acta. 1141, 65-74.
- Zadila SH, Saz J and Pasto DJ (1997) 2- methylacetoacetate Reductase and possible propionyl coenzyme A condensing enzyme activity in branched chain volatile fatty acid synthesis by Ascaris lumbricoides. J. Bio. Chem. 252(12), 4215-4224.
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution 3.0 License.