Total views : 519
A Mathematical Model to Control the Transmission of Thalassemia Disease using Pure Fractions
Objectives: In this paper, we apply the concept of pure fractions to create a mathematical model for the control of Thalassemia disease. Methods: The theory of pure fractions has generated various properties that make it suitable for formalizing the uncertain information upon which medical diagnosis and treatment is usually based. In this study we use pure fraction to generate a mathematical model for Thalassemia disease diagnosis. Findings: Thalassemia disease is one of the medical problems which could be controlled by premarital screening. This disease has major sign and symptoms in the first year of life. The objective of the work is to diagnose Thalassemia using pure fractions. The proposed model would help the health center to automate Thalassemia risk in future generation and to improve the medical care. Application: The proposed method is apply to various other genetic diseases such as G6PD deficiency etc.
Pure Fraction, Reducibility of Pure Fractions, Thalassemia Disease, Unit- Interval
- Angastiniotis M, Kyriakidou S, Hadijiminas M. How Thalassaemia was controlled in Cyprus. World Health Forum. 1986; 7:291–7.
- De M, Das SK, Bhattacharya DK, et al. The occurrence of beta thalassaemia mutation and its interaction with Hb E in the eastern India. Int J Hematol. 1997; 66(1):31–4.
- Atkin K, Ahmad WIU. Genetic screening and haemoglobinopathies: Ethics, politics and practice. Social Science and Medicine. 1998; 46(3):445–58.
- Cao A, Galanello R. Beta-Thalassemia. Genetics in Medicine. 2010; 12(2):61–76.
- Cooley TB, Witwer ER, Lee P. Anemia in children with splenomegaly and peculiar changes in the bones. Am J Dis Child. 1927; 34:347–63.
- Weatherall JD, Clegg JB. The Thalassaemia syndromes. 3rd ed. Oxford: Blackwell Scientific; 1981. p. 132–74.
- Ghodekar SR. Thalassemia: A review. International Journal of Pharma Research and Development. 2010; 2(10):101–8.
- Trent RJA. Diagnosis of hemoglobinopathies. Clin Biochem. 2006; 27(1):27–38.
- Nienhuis AW. Nathan DG. Pathophysiology and clinical manifestations of the β-Thalassemias. Cold Spring Harb Perspect Med. 2012; 2:1–13.
- Adeyemo TA, Adeyemo WL, Adediran A, et al. Orofacial manifestations of hematological disorders: Anemia and hemostatic disorders. Indian Journal of Dental Research. 2011; 22(3):454–61.
- Madhok S, Madhok S. Dental considerations in Thalassemic patients. IOSR Journal of Dental and Medical Sciences. 2014; 13(6):57–62.
- Eke B. A mathematical simulation of a social norm using fuzzy sets. In: Paul P. Wang editor. Proceedings of the 7th Joint Conference on Information Sciences; 2003. p. 126–7.
- Eke B, Nkwanta A. Mathematical model for the control of the transmission of genetic diseases using pure fractions. International Journal of Pure and Applied Mathematics. 2008; 45:243–54.
- Laird NM, Lange C. The fundamentals of modern statistical genetics. Statistics for Biology and Health. Springer Science+Business Media, LLC; 2011. DOI: 10.1007/978-1-4419-7338-2_2.
- Nguyen HT, Walker EA. A first course in fuzzy logic. 3rd ed. Boca Raton: Chapman and Hall – CRC; 2005.
- Vijayarani S, Sudha S. An efficient clustering algorithm for predicting diseases from hemogram blood test samples. Indian Journal of Science and Technology. 2015 Aug; 8(17):521–23.
- Santhanam T, Ephzibah EP. Heart disease prediction using hybrid genetic fuzzy model. Indian Journal of Science and Technology. 2015; 8(9):797–803.
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution 3.0 License.