• P-ISSN 0974-6846 E-ISSN 0974-5645

Indian Journal of Science and Technology

Article

Effect of passive smoking on heavy metals concentration in blood and follicular fluid of patients on going ICSI
  • VIEWS 1296
  • PDF 338

Indian Journal of Science and Technology

DOI: 10.17485/IJST/v13i29.721

Year: 2020, Volume: 13, Issue: 29, Pages: 2935-2940

Original Article

Effect of passive smoking on heavy metals concentration in blood and follicular fluid of patients on going ICSI

Mohammed F ElMohr1*, Mohamed Faris1, Sayed Bakry2, Heba Hozyen3,Fathy M Elshaer4,5

1Dr Faris Medical Center for Infertility and Human Reproduction, Heliopolis, Cairo, Egypt
2Laboratory of Molecular Biology and Embryology, Zoology Department, Faculty of Science,Al-Azhar University, Nasr City, Cairo, Egypt
3Animal reproduction & Artificial Insemination Department, Veterinary Research Division,National Research Centre, Dokki, Cairo, Egypt
4Department of Biology, College of Science, Jouf University, Sakaka, Saudia Arabia
5Zoology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt

*Corresponding Author
Email: [email protected]

Received Date:26 May 2020, Accepted Date:27 July 2020, Published Date:11 August 2020

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Purpose: To assess the effects passive smoking and heavy metal concentrations in the blood and follicular fluid on assisted reproductive technology outcome.Methods: A prospective study was conducted between March 2017 and January 2018 in population consisted of 75 female patients undergoing an In vitro fertilization (IVF) cycle at Dr. Faris Medical center for Infertility and Human Reproduction located on Heliopolis, Cairo, Egypt; with unexplained infertility who underwent intracytoplasmic sperm injection (ICSI) using GnRH-antagonist protocol. Concentrations of three toxic metals Cadmium (Cd), Lead (Pb) and Arsenic (As) were measured both in blood sera and follicular fluid specimens. Patients were evaluated in two groups both undergoing ICSI; the first group consisted of patients who does not smoke or exposed to smoking (n=28) and the group passive smoker females (n=47). Results: These three heavy metals were significantly higher in serum and follicular fluid of passive smoking females (P<0.05). Also, higher concentrations of Cd, Pb and As were found in follicular fluid of passive smoking patients in comparison with non-smoker females. However, concentrations of Cd and Pb were not significantly different between both serum and follicular fluid. Conclusion: Passive smoking could affect levels of Cd, Pb and As in serum and follicular fluid of females undergoing Intra Cytoplasmic Sperm Injection (ICSI).

Keywords: Cadmium (Cd); Lead (Pb); Arsenic (As); Follicular fluid (FF); Intra Cytoplasmic Sperm Injection (ICSI); heavy metals

References

  1. Talhout R, Schulz T, Florek E, Benthem JV, Wester P, Opperhuizen A. Hazardous Compounds in Tobacco Smoke. International Journal of Environmental Research and Public Health. 2011;8(2):613–628. Available from: https://dx.doi.org/10.3390/ijerph8020613
  2. Rodgman A, Perfetti TA. The Chemical Components of Tobacco and Tobacco Smoke. Boca Raton FL USA. CRC Press. 2009.
  3. World Health Organization, International Agency for Research on Cancer: Lyon, France Tobacco Smoke and Involuntary Smoking. In: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. (Vol. 83) Lyon, France. 2004.
  5. Hussain M, Mumtaz S. E-waste: impacts, issues and management strategies. Reviews on Environmental Health. 2014;29(1-2). Available from: https://dx.doi.org/10.1515/reveh-2014-0016
  6. Tolunay HE, Şükür YE, Ozkavukcu S, Seval MM, Ateş C, Türksoy VA, et al. Heavy metal and trace element concentrations in blood and follicular fluid affect ART outcome. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2016;198:73–77. Available from: https://dx.doi.org/10.1016/j.ejogrb.2016.01.001
  7. Fortea PG, Corcia IC, Rosado AR, Mesa EG. Correlation of Four Toxic Elements Concentrations in Hair and Follicular Fluid Collected from Women Undergoing in vitro Fertilization. Journal of Clinical Toxicology. 2016;06(05):322. Available from: https://dx.doi.org/10.4172/2161-0495.1000322
  8. Sun Y, Wang W, Guo Y, Zheng B, Li H, Chen J, et al. High copper levels in follicular fluid affect follicle development in polycystic ovary syndrome patients: Population-based and in vitro studies. Toxicology and Applied Pharmacology. Toxicology and Applied Pharmacology. 2019;(365) 101–111. Available from: https://doi.org/10.1016/j.taap.2019.01.008
  9. Bloom MS, Kim K, Kruger PC, Parsons PJ, Arnason JG, Steuerwald AJ, et al. Associations between toxic metals in follicular fluid and in vitro fertilization (IVF) outcomes. Journal of Assisted Reproduction and Genetics. 2012;29(12):1369–1379. Available from: https://dx.doi.org/10.1007/s10815-012-9882-z
  10. Kruger PC, Bloom MS, Arnason JG, Palmer CD, Fujimoto VY, Parsons PJ. Trace elements in human follicular fluid: development of a sensitive multielement ICP-MS method for use in biomonitoring studies. Journal of Analytical Atomic Spectrometry. 2012;27(8):1245. Available from: https://dx.doi.org/10.1039/c2ja30053b
  11. Galusha A, Haig AC, Bloom MS, Kruger PC, McGough A, Lenhart N, et al. Ultra-trace element analysis of human follicular fluid by ICP-MS/MS: pre-analytical challenges, contamination control, and matrix effects. Journal of Analytical Atomic Spectrometry. 2019;34(4):741–752. Available from: https://dx.doi.org/10.1039/c8ja00423d
  12. Agency for Toxic Substances and disease Registry (ATSDR) Toxicological profile for lead. U.S. Department of Health and Human Services. U.S. Department of Health and Human Services. Public Health Service. Available from: https://www.ncbi.nlm.nih.gov/books/NBK158766/pdf/Bookshelf_NBK158766.pdf
  13. Gökmen IG, El-Agha O. Smoking Habits and Cadmium Intake in Turkey. Biological Trace Element Research. 2002;88(1):31–44. Available from: https://dx.doi.org/10.1385/bter:88:1:31
  14. Batariova A, Spevackova V, Benes B, Cejchanovaa M, Smıda J, Cerna M. Blood and urine levels of Pb, Cd and Hg in the general population of the Czech Republic and proposed reference values. Int. J. Hyg. Environ. Health. 2006;(209) 359–366. Available from: https://doi.org/10.1016/j.ijheh.2006.02.005
  15. Richter P, Faroon O, Pappas RS. Cadmium and Cadmium/Zinc Ratios and Tobacco-Related Morbidities. International Journal of Environmental Research and Public Health. 2017;14(10):1154. Available from: https://dx.doi.org/10.3390/ijerph14101154
  16. Badea M, Luzardo OP, González-Antuña A, Zumbado M, Rogozea L, Floroian L, et al. Body burden of toxic metals and rare earth elements in non-smokers, cigarette smokers and electronic cigarette users. Environmental Research. 2018;166(166):269–275. Available from: https://dx.doi.org/10.1016/j.envres.2018.06.007
  17. Berthiller J, Sasco AJ. Smoking (active or passive) in relation to fertility, medically assisted procreation and pregnancy. J Gynecol Obstet Biol Reprod (Paris). 2005;34(1):3–47. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15980772
  18. Dorne JL, Kass GE, Bordajandi LR, Amzal B, Bertelsen U, Castoldi AF, et al. Human risk assessment of heavy metals: Principles and applications. Met Ions Life Sci. 2011;8:27–60. Available from: https://www.ncbi.nlm.nih.gov/pubmed/21473375
  19. Bonanno LJ, Freeman NCG, Greenberg M, Lioy PJ. Multivariate Analysis on Levels of Selected Metals, Particulate Matter, VOC, and Household Characteristics and Activities from the Midwestern States NHEXAS. Applied Occupational and Environmental Hygiene. 2001;16(9):859–874. Available from: https://dx.doi.org/10.1080/10473220121418
  20. Massadeh A, Gharibeh A, Omari K, Al-Momani I, Alomari A, Tumah H, et al. Simultaneous Determination of Cd, Pb, Cu, Zn, and Se in Human Blood of Jordanian Smokers by ICP-OES. Biol Trace Elem Res. 2009;(133) 1–11. Available from: https://doi.org/10.1007/s12011-009-8405-y
  22. Khan FA, Das GK, Pande M, Mir RA, Shankar U. Changes in biochemical composition of follicular fluid during reproductive acyclicity in water buffalo (Bubalus bubalis) Animal Reproduction Science. 2011;127(1-2):38–42. Available from: https://dx.doi.org/10.1016/j.anireprosci.2011.07.013
  23. Younglai EV, Foster WG, Hughes EG, Trim K, Jarrell JF. Levels of Environmental Contaminants in Human Follicular Fluid, Serum, and Seminal Plasma of Couples Undergoing In Vitro Fertilization. Archives of Environmental Contamination and Toxicology. 2002;43(1):121–126. Available from: https://dx.doi.org/10.1007/s00244-001-0048-8
  24. Akarsu SA, Yilmaz M, Niksarlioglu S, Kulahci F, Risvanli A. Radioactivity, heavy metal and oxidative stress measurements in the follicular fluids of cattle bred near a coal-fired power plant. The Journal of Animal & Plant Sciences. 2017;27(2):373–378. Available from: http://www.thejaps.org.pk/docs/v-27-2/03.pdf
  25. Galażyn-Sidorczuk M, Brzóska MM, Moniuszko-Jakoniuk J. Estimation of Polish cigarettes contamination with cadmium and lead, and exposure to these metals via smoking. Environmental Monitoring and Assessment. 2008;137(1-3):481–493. Available from: https://dx.doi.org/10.1007/s10661-007-9783-2
  26. Richter P, Bishop E, Wang J, Swahn M. Tobacco Smoke Exposure and Levels of Urinary Metals in the U.S. Youth and Adult Population: The National Health and Nutrition Examination Survey (NHANES) 1999–2004. International Journal of Environmental Research and Public Health. 2009;6(7):1930–1946. Available from: https://dx.doi.org/10.3390/ijerph6071930
  27. Macaluso M, Wright-Schnapp TJ, Johnson CA, Satterwhite R, Pulver CL, A. A public health focus on infertility prevention, detection, and management. Fertil Steril. 2008;16. Available from: https://doi.org/10.1016/j.fertnstert.2008.09.046
  29. Capcarová M, Kolesárová A. Trace elements in follicular fluid and their effects on reproductive functions. Biotechnology and Food Sciences. 2012;(1) 1039–1044. Available from: https://www.jmbfs.org/wp-content/uploads/2013/09/jmbfs-Capcarova-2013.pdf
  30. Practice Committee of the American Society for Reproductive Medicine Smoking and infertility. Fertil. Steril. . 2008;90(3):254–259. Available from: https://doi.org/10.1016/j.fertnstert.2008.08.035
  31. Hull MG, North K, Taylor H, Farrow A, Ford WC. The Avon Longitudinal Study of Pregnancy and Childhood Study Team Delayed conception and active and passive smoking. . Fertil Steril. 2000;74(4):725–733. Available from: https://doi.org/10.1016/s0015-0282(00)01501-6
  33. Hozyen HF, Ahmed HH, Essawy GES, Shalaby SIA. Seasonal changes in some oxidant and antioxidant parameters during folliculogenesis in Egyptian buffalo. Animal Reproduction Science. 2014;151(3-4):131–136. Available from: https://dx.doi.org/10.1016/j.anireprosci.2014.10.005
  34. Zhang X, Wang T, Song J, Deng J, Sun Z. Study on follicular fluid metabolomics components at different ages based on lipid metabolism. Reproductive Biology and Endocrinology. 2020;(18) 1–8. Available from: https://doi.org/Doi.org/10.1186/s12958-020-00599-8
  35. Oktem O, Urman B. Understanding follicle growth in vivo. Human Reproduction. 2010;25(12):2944–2954. Available from: https://dx.doi.org/10.1093/humrep/deq275
  36. Silberstein T, Saphier O, Paz-Tal O, Gonzalez L, Keefe DL, Trimarchi JR. Trace element concentrations in follicular fluid of small follicles differ from those in blood serum, and may represent long-term exposure. Fertility and Sterility. 2009;91(5):1771–1774. Available from: https://dx.doi.org/10.1016/j.fertnstert.2008.02.007

Copyright

© 2020 ElMohr et al..This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Indian Society for Education and Environment (iSee).

  • 10 August 2020

Year: 2020, Volume: 13, Issue: 29

Article Metrics


Post Graduate Fellowship in Research Communication

More articles

DON'T MISS OUT!

Subscribe now for latest articles and news.