Indian Journal of Science and Technology
Year: 2012, Volume: 5, Issue: 7, Pages: 1-4
B. Okwandu Ngozika1*, C. Monago comfort2 , A. Uwakwe Austin2 , J. Ifemeje Chineye3 and U. Okeke Chukwubuike4
1 Department of Biochemistry, Madonna University Elele Campus, Nigeria.
2 Department of Biochemistry, University of Port Harcourt Choba, Nigeria.
3 Department of Biochemistry, Anambra State University Uli, Nigeria.
4 Department of Prosthesis and Orthopedic Technology, School of Health Technology Federal University of Technology, Owerri Nigeria. [email protected]
*Author For Correspondence
B. Okwandu Ngozika
Department of Prosthesis and Orthopedic Technology
Email: [email protected]
The present study was conducted on the rat population of animal house in Madonna University, Elele Campus, Nigeria to evaluate the status of some biochemical parameters of rats administered with varied concentrations of chlorpheniramine maleate (piriton), cyproheptadine hydrochloride (cypron), and clemastine fumarate (tavagyl). Blood samples and liver organ were collected from 51 male and female albino rats, 48 were given different concentrations of each of the antihistamine drugs for 30 days, while 3 rats were used as control. Alanine amino transferase (ALT) activity and Aspartate amino transferase (AST) were lower in the control group compare to the groups administered with piriton, Cypron, and Tavagyl at 0.04mg/ml, 0.02mg/ml, 0.01mg/ml, and 0.005mg/ml. From the above results it is concluded that piriton, cypron, and Tavagyl increased the activities of AST and ALT enzymes. Keyword: Alanine amino transferase, Aspartate amino transferase, piriton, cypron, and Tavagyl, Rat
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