Indian Journal of Science and Technology

Abstract

Background/Objectives: The study represents theoretical and practical justification of employing mesodiencephalic modulation as a pathogenetic method of correction within the framework of general adaptation syndrome. Methods/ Statistical Analysis: The study applied scientific analysis of literature together with structural and functional analysis within systemic approach. Based on familiarizing with factual materials, a formalizing and analytical review of theoretical data has been compiled. The data have been used for generating working hypothesis and making a comparative and deductive assessment of the assumptions. Theoretical data were generalized by scientific synthesis. The assumptions have been proven applying the results of clinical observations. Findings: Principal pathogenetic mechanisms responsible for the formation of general adaptation syndrome have been studied. The universal nature of stress development stages has been demonstrated at physiological level independently of the character of its conditioning factors. The most significant manifestations of adaptation syndrome observed in the clinical pattern of different nosological forms have been identified. With regard to the urgency of the issue of correcting systemic abnormalities caused by the stress response, general medical practice has outlined principal directions for developing pathogenetic therapy methods. The innovative approach employing mesodiencephalic modulation has been suggested for the complex treatment of systemic stress disorders. Comparative analysis established pathogenetic correlations between the key stress-generating mechanisms and therapeutical modalities of this method of treatment. Improvements/Applications: Practicability of wider introduction of mesodiencephalic modulation into the system of practical healthcare as a basic element of auxiliary pathogenetic therapy has been scientifically substantiated.

Keywords: Cranial Electrotherapy Stimulation, Gamma-Aminobutyric Acid (GABA), General Adaptation Syndrome, Mesodiencephalic Modulation, Opioidergic System, Stress-Limiting System