• P-ISSN 0974-6846 E-ISSN 0974-5645

Indian Journal of Science and Technology


Indian Journal of Science and Technology

Year: 2021, Volume: 14, Issue: 34, Pages: 2731-2741

Original Article

Synthesis, Spectral Characterisation and Cytotoxic Evaluation of Substituted Sulfonamide Schiff Bases

Received Date:21 May 2021, Accepted Date:15 September 2021, Published Date:20 October 2021


Objectives: To synthesize Schiff bases i.e 4-((2-hydroxybenzylidene)-amino–N-(5-methyl-1,2-oxozol-3- yl)benzene sulphonamide (L1), 4-((2-hydroxy benzylidene)-amino-N-(thiazol-yl)benzene sulphonamide (L2), 4-((2-hydroxybenzylidene)amino-N-(pyridin-2-yl)benzene sulphonamide by theaction of 2-hydroxybenzaldehyde with sulfathiazole/ sulfamethoxazole/ sulfapyridine in ethanolic media. Methods: The Schiff bases obtained were characterized by analytical data, IR, UV, 1H- NMR, 13C-NMR, Mass spectrum and monitored for cytotoxic activity against human breast cancer cell [MDA MB -231] line. Findings: The Schiff bases behaves as a bidentate ligand with oxygen and nitrogen as chelating positions and coordinates via phenolic oxygen and azomethine nitrogen. The composition of the ligands has been established by elemental analysis. Structural features and bonding mode of the Schiff bases have been proposed by spectral methods. The evaluated synthesized ligand  shows excellent cytotoxic activity towards breast cancer cell line. Novelty: The evaluated highly biologically active L1 and L3 shows desirable cytotoxic activity towards [MDA MB -231] breast cancer cell line. The better IC50 value of the Schiff base ligands upgrades as chemotherapeutic agents which leads to drug formulation and induces DNA binding studies.

Keywords: 4-amino-N-(1; 3-thiazol-2-yl)benzenesulfonamide; 4-amino-N-(5-methyl-1; 2-oxazol-3-yl)-benzenesulfonamide; 4-amino-N-(pyridin-2-yl)benzenesulphonamide; 2-hydroxy benzaldehyde; cytotoxicity


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© 2021 Govindaraj et al.  This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Published By Indian Society for Education and Environment (iSee)


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