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Study Results of a New Centrifugal Pump for Medical Perfusion Complex to Restore and Maintain the Viability of the Isolated Donor Liver
Objectives: The article deals with experimental studies of original centrifugal pump developed in the Central Research Institute of Robotics and Technical Cybernetics (Saint-Petersburg, Russia) and designed for the use in apparatus for machine perfusion of the donor liver. Methods: In 4 series of experiments the traumatic effect of the pump on blood cells and changes in certain parameters during the perfusion with donor blood were studied. Blood samples were taken before the perfusion and at 60, 120, 240 minutes of the perfusion. Blood samples were analyzed using spectrophotometer and hematologic analyzer. A study of pressure-flow characteristics of the centrifugal pump incorporated into the developed apparatus for machine perfusion with arterial and venous lines was also performed. Findings: After 4 hours of donor blood circulation in the closed circuit by means of the studied pump there were no significant changes in blood parameters except for increase in free hemoglobin concentration which was comparable to what happens during the perfusion with a roller pump. The centrifugal pump provides pressure-flow characteristics required for perfusion of donor liver both in arterial and venous lines. In the operating area of hydrodynamic characteristics of the pump incorporated into the apparatus for machine perfusion of donor liver the fluid pressure in the arterial and venous lines reaches 2.7 and 2.3 m, respectively. Improvements: In experimental study it was shown that original centrifugal pump is safe and effective in terms of blood perfusion and it looks promising for the use in the apparatus for machine perfusion of the donor liver.
Blood Trauma, Centrifugal Pump, Liver Transplant, Machine Perfusion, Peristaltic Pump, Pressure-Flow Characteristics.
- McAnulty JF. Hypothermic organ preservation by static storage methods: Current status and a view to the future. Cryobiology. 2010; 60(S3):13-19. Crossref PMid:19538951
- Hashimoto K, Miller C. The use of marginal grafts in liver transplantation. Journal of Hepato biliary Pancreatic Science. 2008; 15(2):92-101.
- Mulholland JW, Shelton JC, Luo XY. Blood flow and damage by the roller pumps during cardiopulmonary bypass. Journal of Fluids and Structures. 2005; 20(1):129-140. Crossref
- Lopota AV, Gryaznov NA, Velichko OV. Technical Support of Preclinical Hydrodynamic and Functional Tests of New Medical Mechatronic Peristaltic Blood Pumps Developed by Central Research Institute of Robotics and Cybernetics. American Journal of Applied Sciences. 2016; 13(2):184-88. Crossref.
- Hessel EA. Cardiopulmonary bypass circuitry and cannulation techniques. Baltimore: Williams and Wilkins: Gravlee GP, Davis RF, Utley JR, (Eds.) Cardiopulmonary bypass, principles and practice. 1993; p. 55-92.
- Kurusz M, Shaffer CW, Christman EW, Tyers GF. Runaway pump head: new cause of gas embolism during cardiopulmonary bypass. The Journal of Thoracic and Cardiovascular Surgery. 1979 May; 77(5):792-95. PMid:431117
- Lynch MF, Peterson D, Baker V. Centrifugal blood pumping for open-heart surgery. Minnesota Medicine. 1978; 61(9):536-7. PMid:703742
- Curtis JJ. Centrifugal mechanical assist for postcardiotomy ventricular failure. Seminars in Thoracic and Cardiovascular Surgery. 1994; 6(3):140-6. PMid:7948289
- Nishida H, Shibuya M, Kitamura M. Percutaneous cardiopulmonary support as the second generation of venoarterial bypass: current status and future direction. Artificial Organs. 1993; 17(11):906-13. Crossref PMid:8110058
- Black MD, Coles JG, Williams WG et al. Determinants of success in pediatric cardiac patients undergoing extracorporeal membrane oxygenation. The Annals of Thoracic Surgery. 1995; 60(1):133-8. Crossref.
- Kolff J, McClurken JB, Alpern JB. Beware centrifugal pumps: not a one-way street, but a dangerous siphon! The Annals of Thoracic Surgery. 1990; 50(3):512. Crossref
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