Eco-friendly Spectrophotometric analysis of Mefenamic acid (poorly water-soluble drug) using the mixed solvency concept

Ketan Soni; Kavita Sharma

doi:10.17485/IJST/v14i28.476

Article

Eco-friendly Spectrophotometric analysis of Mefenamic acid (poorly water-soluble drug) using the mixed solvency concept

VIEWS 2028
PDF 341

Indian Journal of Science and Technology

DOI: 10.17485/IJST/v14i28.476

Year: 2021, Volume: 14, Issue: 28, Pages: 2337-2341

Original Article

Eco-friendly Spectrophotometric analysis of Mefenamic acid (poorly water-soluble drug) using the mixed solvency concept

Ketan Soni^1*, Kavita Sharma²

¹Research Scholar, Shri Vaishnav Vidyapeeth Vishwavidyalaya, Indore, Tel.: 9827039131
²Professor & Co-ordinator, Shri Vaishnav Institute of Forensic Science, SVVV, Indore

*Corresponding Author
Tel: 9827039131
Email: [email protected]

Received Date:19 March 2021, Accepted Date:08 July 2021, Published Date:20 August 2021

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Objectives: To investigate an eco-friendly method to enhance the solubility of Mefenamic acid. The present investigation was to employ these hydrotropic solutions to extract the drugs from their dosage forms, precluding the use of costlier and harmful organic solvents. Methodology: Mefenamic acid was analyzed by using UV Visible spectrophotometer (Model 1800, Shimadzu), and its solubility (poorly water-soluble drug) measured by mixed solvency method. Sodium caprylate solution was used as a hydrotropic solubilizing agent. Findings: The solubility of the Mefenamic acid drug in water was very low at about 0.2 mg/ml and the solubility of Mefenamic acid in the 20% sodium caprylate solution was 10 mg/ml. The value of percentage estimation obtained was from 98.6 (tablet II) to 98.8 (tablet I). This value is obtained near to 100% hence, we can say that the proposed method is correct. Standard deviation (0.173 to 0.346), percentage coefficient of variation (0.175 to 0.350) and the value of standard error (0.101 to 0.202) are also very low to validate the accuracy of the proposed method. Novelty: Mixed solvency concept can be utilized for spectrophotometric estimation of poorly water-soluble drugs from their bulk drug samples to avoid the use of organic solvents that provide a new, economical, environmentally friendly, safe, and reliable analytical mechanism.

Keywords: Mixed solvency; solubility; hydrotropic; mefenamic acid; sodium caprylate

References

Kumar MR, Arpna I. Formulation and evaluation of aceclofenac injection made by mixed hydrotropic solubilization technique. Iranian journal of pharmaceutical research. 2010;9(3):233–242. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/pmc3863437/
Vikas P, Santosh T, Santosh B, Rupali S, Lalit G. Spectrophotometric estimation of cefprozil by using Different hydrotropic agents. International Journal of Pharmacy and Pharmaceutical Sciences. 2010;2(1):82–87. Available from: https://www.ijppsjournal.com/Vol2Issue1/272.pdf
Swathi CH, Subrahmanyam C, Kedarnath SA, Puvvadir SB. Solubilization of mefenamic acid. International Journal of Pharmacy and Technology. 2011;3:3267–3276. Available from: https://www.researchgate.net/publication/289542088_Solubilization_of_mefanamic_acid
Kumar UMR, Nandan J, Jhalak P, Mittal MK, Chand. New spectrophotometric estimation of naproxen tablet formulation employing mixed solvency concept (at 331 nm) International Journal of Pharmacy and Technology. 2011;3(4):3618–3623. Available from: https://www.ijptonline.com/volume-3-issue-4
Kumar UMR, Navneet J, Jitendra P, Mittal P, Ravikant. New spectrophotometric analysis of gatifloxacin tablets utilizing mixed solvency concept (at 288 nm) Der Pharmacia Lettre. 2012;4(1):1–4. Available from: 10.13140/RG.2.2.35781.60646
Kumar MR, Rajendra S. Formulation development and evaluation of injection of poorly soluble drug using mixed solvency concept. International Journal of Pharma and Bio Sciences. 2012;3(1):179–189.
Ruchi J, Nilesh J, Kumar MR, Kumar JS. Quantitative estimation of levofloxacin and ornidazole by uv spectrophotometer: A mixed hydrotropy solubilization approach. International Journal of Pharmaceutical Sciences and Research. 2013;4(1):3073–3079. Available from: https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.369.1629&rep=rep1&type=pdf
Soni LK, Solanki SS, Maheshwari RK. Solubilization of poorly water-soluble drug using mixed solvency approach for aqueous injection. Journal of Pharmaceutical Research International. 2014;4(5):549–568. Available from: 10.9734/BJPR/2014/4281
Kumar MR. Solid as solvent”- Novel spectrophotometric analysis of norfloxacin tablets using phenol as solvent”. International Journal of Current Pharmaceutical Research. 2014;6(4):76–78. Available from: https://innovareacademics.in/journals/index.php/ijcpr/article/view/3404
El-Houssieny BM, El-Dein EZ, Hm EM. Enhancement of solubility of dexibuprofen applying mixed hydrotropic solubilization technique. Drug discoveries & therapeutics. 2014;31(4):178–184. Available from: 10.5582/ddt.2014.01019
Jyotsana M, Kiran P, Kamal D. Solubility enhancement studies on lurasidone hydrochloride using mixed hydrotropy. International journal of pharmaceutical investigation. 2015;5(2):114–120. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/pmc4381388/
Kumar MR, Fouzdar A. Solid as solvent”- Novel spectrophotometric analytical technique for ornidazole tablets using solids (eutectic liquid of phenol and niacinamide) as solubilizing agents (mixed solvency concept) Indian Drugs. 2015;52:42–45. Available from: http://www.indiandrugsonline.org/download-article?type=Mg==&id=NDU5
Kumar MR, Padiyar A, Putliwala M. Utilization of mixed solvency technique in spectrophotometric analysis of cefiximetrihydrate tablets. International Journal of Pharmaceutical Research and Analysis. 2015;5(1):1–3. Available from: http://www.ijpra.com/File_Folder/1-3(ijpra).pdf
Kumar MR, Jawade S, FA. Formulation development of aqueous injection of poorly soluble drug using mixed hydrotropic solubilization concept and its evaluation. International Journal of Pharmaceutical Sciences and Drug Research. 2015;7(1):8–12. Available from: https://www.ijpsdr.com/index.php/ijpsdr/article/download/370/333
Rajesh M, Kumar S, Akash P, Lovkush P, Tiwari SP. Solid as solvent: novel spectrophotometric analytical technique for quantitative analysis of tinidazole tablets using solids (eutectic liquid of phenol and metformin hydrochloride) as solubilizing agents (mixed solvency concept) The Pharma Innovation Journal. 2016;5(3):1–02. Available from: https://www.thepharmajournal.com/vol5Issue3/Issue_Mar_2016/5-2-10.1.pdf
Sanjay J, Kumar RMR, Kumar N, Indrajeet S. Development and validation of simple UV spectrophotometric method of quantization of Nifedipine in solid dosage formulation using mixed solvency concept. World Journal of Pharmaceutical Research. 2017;6(13):1014–1021. Available from: https://wjpr.net/download/article/1508143963.pdf
Jain R, Jain N, Jain DK, Patel VK, Rajak H, Jain SK. Novel UV spectrophotometer methods for quantitative estimation of metronidazole and furazolidone using mixed hydrotropy solubilization. Arabian Journal of Chemistry. 2017;10(2):151–156. Available from: https://doi.org/10.1016/j.arabjc.2013.09.003
Sanjay J, Kumar RMR, Kumar N, Indrajeet S. New Spectrophotometric Estimation of Frusemide in the Tablets using mixed solvency concept Approach. International Journal of Current Advanced Research. 2017;6(12):8510–8513. Available from: https://dx.doi.org/10.24327/ijcar.2017.8513.1375
Poonam S, Komal R, Ashvini R, Giridhar R, Shital P, Wagh R, et al. Development and validation of mixed hydrotropic solubilization method for spectrophotometric determination of Ornidazole in bulk drug and tablet. Journal of Pharmacy Research. 2017;11(11):1114–1119. Available from: https://jprsolutions.info/files/ms-file-5a10fa89dacd58.89376637.pdf
Kumar MR, Rashmi D. Solid as solvent”- Novel spectrophotometric analytical technique for quantitative estimation of tinidazole in tablets using solids (eutectic liquid of phenol and lignocaine hydrochloride) as solubilizing agents (mixed solvency concept) Journal of Drug Delivery and Therapeutics. 2017;7(3):127–130. Available from: http://jddtonline.info/index.php/jddt/article/view/1437
Kumar MR, Prakhar G, Himanshi G. Formulation development of a model dry injection for reconstitution of poorly water soluble drug ornidazole using mixed solvency concept and its evaluation. International Journal of Science and Research. 2018;7(4):408–414. Available from: https://www.ijsr.net/get_abstract.php?paper_id=ART20181340
Asmat, Raza SN, Khan NA. Hydrotropy: Novel Solubility Enhancement Technique: A Review. International Journal of Scientific progress and research. 2019;10(3):1025–1036. Available from: https://ijpsr.com/bft-article/hydrotrophy-novel-solubility-enhancement-technique-a-review/?view=fulltext
Joshi J, Nainwal N, Saharana VA. Review on hydrotropy: a potential approach for the solubility enhancement of poorly soluble drug. Asian Jouranal of Pharmaceutical and Clinical Research. 2019;12:19–26. Available from: 10.22159/ajpcr.2019.v12i10.34811
Kumar MR, Shruti J, Anjali P, Pawan M, Singh BJ, Neelesh M. Eco-friendly extraction using solids''-A novel application of mixed solvency concept. Journal of Drug Delivery and Therapeutics. 2019;15(2):244–249. Available from: https://pdfs.semanticscholar.org/952f/cea89927451427d2d2c3072e3874e84416d8.pdf
Kumar MR, Apeksha A, Mitali J, Prakash AO. Spectrophotometric analysis of tablets of nalidixic acid using melted niacinamide as solvent. Journal of Drug Delivery and Therapeutics. 2019;15(9):206–208. Available from: http://jddtonline.info/index.php/jddt/article/view/2323

Copyright

© 2021 Soni & Sharma. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Indian Society for Education and Environment (iSee)