• P-ISSN 0974-6846 E-ISSN 0974-5645

Indian Journal of Science and Technology

Article

Evaluation of Anxiolytic Activity of Methanolic Extract of Rhizome of Bergenia ciliata (Pashanbheda) in Swiss Albino Mice
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Indian Journal of Science and Technology

DOI: 10.17485/IJST/v16i46.2990

Year: 2023, Volume: 16, Issue: 46, Pages: 4421-4428

Original Article

Evaluation of Anxiolytic Activity of Methanolic Extract of Rhizome of Bergenia ciliata (Pashanbheda) in Swiss Albino Mice

G Rachana1, Y Jyothi1*, A Deekshitha1, S Harshitha1, Lalhriatpuii1

1Department of Pharmacology, Krupanidhi College of Pharmacy, Bangalore, 560 035,
Karnataka, India

*Corresponding Author
Email: [email protected]

Received Date:23 November 2023, Accepted Date:07 December 2023, Published Date:20 December 2023

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Objectives: To evaluate the possible anxiolytic activity of methanolic extract of Bergenia ciliata rhizome (MEBC) in Swiss albino mice. Methods: The methanolic extract of the rhizome of Bergenia ciliata was tested on various conventional animal models, such as the elevated plus maze, staircase, social interaction, and light/dark model. MEBC with 200mg/kg & 400mg/kg dose in 1% of carboxy methyl cellulose, diazepam with 2mg/kg dose,1% of Carboxy Methyl Cellulose was used as vehicle control in the study. Findings: In the Elevated plus maze model, the numbers of entries in the open arm were 3.1±0.57, 14.5±1.02, 10.8±1.07, and 7.57±0.63 respectively noted for vehicle control, Diazepam (2mg/ml), 200 and 400 mg/kg of MEBC. Similarly, in the Light-dark arena model, the numbers of entries in the dark chamber were 223.67±0.11.59, 102.33±32.893, 188.33±28.992, and 192±25.120, respectively noted for vehicle control, Diazepam (2mg/ml), 200 and 400 mg/kg of MEBC. In the staircase exploration model, the number of steps climbed were 8.61 ± 2.21, 23.41 ± 1.34, 20.32 ± 1.06 and 11.69 ± 1.94 respectively for vehicle control, Diazepam (2mg/ml), 200 and 400 mg/kg of MEBC. In staircase exploration model and social interaction models, MEBC treated group with a low dose (200 mg/kg) revealed a statistically significant (P<0.05) increase in rearing and social contact. This result clearly showed that MEBC-200mg/KG has antianxiety properties when compared to diazepam. Novelty: Bergenia ciliata may prove to be a useful source of natural psychotherapy agents to treat a range of illnesses associated with anxiety.

Keywords: Anxiety, Poor sleep, Elevated Plus Maze, Anxiolytics, Antioxidant

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Copyright

© 2023 Rachana et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Indian Society for Education and Environment (iSee)

  • 22 December 2023

Year: 2023, Volume: 16, Issue: 46

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