Indian Journal of Science and Technology
DOI: 10.17485/ijst/2010/v3i9.10
Year: 2010, Volume: 3, Issue: 9, Pages: 994-1000
Original Article
Kishwar Sultana1 , Najm ul Hassan2 , M. Shifa khan1 , Mohsin Abbas khan1 , Khadija Shahid1 , Humaira Nadeem1 and Junaid Umar Alvi3*
1 Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad-44000, Pakistan
2 School of Pharmacy, University of Lahore Islamabad Campus, Islamabad Pakistan
3 Genera Pharmaceuticals, I-9/2 Islamabad Pakistan
[email protected]
Ferrous fumarate has poor flow properties which cause compression problems. When ferrous fumarate is manufactured in combination with folic acid, the same problem is encountered. Therefore, a wet-granulation method is used for tablet manufacturing, which is a time-consuming and energy-wasting process compared to a directcompression method. In the present work, ferrous fumarate and folic acid (combination) tablets have been prepared using an optimized direct-compression technique that decreases the total manufacturing time of a batch (approx. 1.5 million tablets) from 24-28 h to only 2–3 h. The direct-compression technique is a simple and cost-effective method of manufacturing ferrous fumarate and folic acid (combination) tablets. Several formulations were developed using different proportions of avicel PH102, talcum, magnesium stearate, sodium lauryl sulfate, sugar, primojel, lactose, PVPK-30 and aerosil. Ten formulations were found to fulfill the specified criteria.
Keywords: Ferrous fumarate, folic acid, tablets, direct compression, combination.
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