In-Vitro Studies on Alpha Amylase and Alpha Glucosidase Inhibitory Activities of Synthesized Novel Sn(IV) Complexes of Schiff Base Ligand

Kamal Kant Serawat; Kavita Kumari Meena; R K Gunsaria

doi:10.17485/IJST/v16i30.370

Article

In-Vitro Studies on Alpha Amylase and Alpha Glucosidase Inhibitory Activities of Synthesized Novel Sn(IV) Complexes of Schiff Base Ligand

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Indian Journal of Science and Technology

DOI: 10.17485/IJST/v16i30.370

Year: 2023, Volume: 16, Issue: 30, Pages: 2297-2303

Original Article

In-Vitro Studies on Alpha Amylase and Alpha Glucosidase Inhibitory Activities of Synthesized Novel Sn(IV) Complexes of Schiff Base Ligand

Kamal Kant Serawat^1*, Kavita Kumari Meena¹, R K Gunsaria²

¹Research Scholar, Department of Chemistry, University of Rajasthan, Jaipur, 302004, Rajasthan, India
²Associate Professor, Department of Chemistry, University of Rajasthan, Jaipur, 302004, Rajasthan, India

*Corresponding Author
Email: [email protected]

Received Date:19 February 2023, Accepted Date:03 July 2023, Published Date:08 August 2023

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Objectives: The current study is concerned with creatingSn(IV) complex with a novel synthesize schiff base ligand2,3-dimethyl-N’-(2-oxo-2,3-dihydro-1Hindol- 3-yl)benzhydrazide and were investigated for the Inhibition of alphaamylase and alpha-glucosidase enzyme. Methods: Ligand was synthesized by using isatin and 2,3-dimethylbenzoic acid hydrazide. n-Bu3SnCl and n- Bu2SnCl2 were used for the synthesis of metal complexes. The structures of the ligand and metal complexes were confirmed by spectroscopic analysis i.e. 1H-NMR, IR and MS. Findings: A clinical disease known as diabetes mellitus is defined by hyperglycemia, in which a greater than normal amount of glucose circulates in the blood plasma. Inhibitors of alpha amylase and alpha glucosidaseare used to better manage hyperglycemia in type 2 diabetes mellitus. Synthesized metal complexes were investigated for the Inhibition of alpha-amylase and alpha-glucosidase enzyme. In the alpha amylase inhibition assay, L-1 (118.8811.14), MC-1 (76.909.55), and MC-2 (73.288.31) all displayed 50% alpha amylase inhibition activity. The IC50 values for [L-1], [MC-1], and [MC-2] in the alpha glucosidase inhibition experiment were 128.8610.27, 76.909.55, and 73.288.31 g/ml, respectively. Observed data revealed that MC-2 have higher inhibition activity. Novelty: Anti-hyperglycemia activity was investigated by using newly synthesized metal complexes.

Keywords: Schiff Base; Sn(IV); Hyperglycemia; Alpha Amylase; Alpha Glucosidase

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Copyright

© 2023 Serawat et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Indian Society for Education and Environment (iSee)