Indian Journal of Science and Technology

Abstract

Objective: To assess the oxidative stress in plasma and erythrocytes of prostate cancer patients by measuring the levels of lipid peroxidation and antioxidants. Patients & methods: 20 newly diagnosed prostate cancer patients and an equal number of age between 55-70 years and sex matched normal subjects from Guntur, AP, India were chosen for the study. Biochemical parameters like TBARS, enzymatic antioxidants, non enzymatic antioxidants were analyzed and monitored in plasma and erythrocyte membranes of normal and prostate cancer patients. Results: The subjects were ranging in age from 55-70 years. Changes observed from baseline expressed as mean ±SD in plasma of normal and prostate cancer patients are TBARS 3.8±0.2, 6.9±0.52(P<0.001), vitamin E 1.4±0.06,1.28±0.09,vitamin C 1.39±0.07, 1.29±0.06, reduced glutathione 52.7±4.2, 42.8±2.9 (p<0.01), glutathione peroxidase 189.8±23.4, 160±12.7(p<0.01), catalase 0.76±0.07, 0.56±0.04 (p<0.01)respectively and TBARS 0.33±0.04, 0.92±0.07(P<0.001)reduced glutathione 54.9±3.8, 44.8±2.7(p<0.01) vitamin E 2.31±0.19, 1.76±0.09(p<0.01) respectively in erythrocyte membrane. TBARS 4.3±0.51, 5.7±0.42(P<0.001) superoxide dismutase 4.71±0.52, 4.32±0.34, catalase 1.7±0.09, glutathione peroxidase 22.2±1.7, 20.6±1.7(p<0.01) in erythrocyte of normal and prostate cancer patients. Conclusion: The antioxidants and lipid peroxides levels in prostate cancer patients were altered when compared to normal patients. The picture of prostate cancer in India is potentially underestimated owing to scant data.
Keywords: Oxidative stress, lipid peroxidation, antioxidants, prostate cancer.