Indian Journal of Science and Technology
Year: 2012, Volume: 5, Issue: 2, Pages: 1-5
Fatemeh Soleimani1 , Mohammad Sadeghi2* and Hadis Shahsavari3
1,3 Young researchers club, Islamic Azad University, Khorramabad Branch, Khorramabad,Iran 2Department of Chemistry, [email protected]
*Author For Correspondence
Department of Chemistry,
The polysaccharide, kappa-carrageenan (κC) was chemically modified to achieve a novel superabsorbent hydrogel via graft copolymerization of acrylamide (AAm) onto the substrate followed by alkaline hydrolysis. Ammonium persulfate (APS) and N,N' -methylene bisacrylamide (MBA) were used as a free-radical initiator and a crosslinker, respectively. The saponification reaction was carried out using sodium hydroxide aqueous solution. Either κC-g-PAAm or hydrolyzed κC-g-PAcA was characterized by FTIR spectroscopy. The effect of media variables such as alkaline hydrolysis conditions (i.e., NaOH concentration, hydrolysis time and temperature) were systematically optimized to achieve a hydrogel with swelling capacity as high as possible. Absorbency of superabsorbing hydrogels was examined in buffer solutions with pH ranged 1-13. Also, the pH reversibility and on-off switching behavior, at pH 2.0 and 9.0, makes the synthesized hydrogels as a good candidate for controlled delivery of bioactive agents. Finally, the κC-g-PAcA hydrogel exhibited a pH-responsiveness character so that a swelling-deswelling pulsatile behavior was recorded at pH 1.2 and 7.4. In addition, the delivery behavior of Acetaminophen from the hydrogel bead was studied.
Keywords: Carrageenan; hydrogel; superabsorbent; pH-sensitive; Acetaminophen
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