Preparation, Structures and Antimicrobial Activity of Ni(II) Complexes on the Base of Enrofloxacin with Dicumarol Derivative

Nikita Prajapati; Shalini Chaturvedi

doi:10.17485/IJST/v16i12.2445

Article

Preparation, Structures and Antimicrobial Activity of Ni(II) Complexes on the Base of Enrofloxacin with Dicumarol Derivative

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Indian Journal of Science and Technology

DOI: 10.17485/IJST/v16i12.2445

Year: 2023, Volume: 16, Issue: 12, Pages: 931-940

Original Article

Preparation, Structures and Antimicrobial Activity of Ni(II) Complexes on the Base of Enrofloxacin with Dicumarol Derivative

Nikita Prajapati¹, Shalini Chaturvedi^2*

¹Department of chemistry, Silver Oak Institute of Science, Silver Oak University, Ahmedabad Gujarat, India
²Department of Chemistry, Shri R K Parikh Arts and Science College Petlad, Anand, Gujarat, India

*Corresponding Author
Email: [email protected]

Received Date:21 December 2022, Accepted Date:13 February 2023, Published Date:28 March 2023

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Objective: To synthesize Ni(II) complexes on the base of enrofloxacin with dicumarol derivative and to investigate their antioxidant and antimicrobial potentials. Methods: Ni(II) complexes have been synthesized by classical thermal methods by mixing aqueous metal solutions with ethanol ligands and enrofloxacin in a 1:1 molar ratio. A biologically strong ligand was prepared by refluxing a dicoumarol derivative in aldehyde and ethanol. The structures of the ligands and their nickel complexes were investigated and confirmed by elemental analysis, FT-IR, 1H-NMR, 13C-NMR and mass spectroscopy. The thermal behavior of newly synthesized mixed-ligand Ni(II) complexes was studied by thermogravimetric analysis. Ferric-reducing antioxidant power (FRAP) (antioxidant activity) of all complexes were measured. All the compounds were screened for their antimicrobial activity against E. coli; P. aeruginosa; S. pyogenes; C. albicans and A. niger using Luria Broth dilution method for MIC values. Both the ligand and its complex were screened for antioxidant and antimicrobial activity in vitro. Findings: Antioxidant and antimicrobial activities of complexes were found to be better than the parent ligands used for complex formation. MIC values for complex C5 (-CH3 derivative) were found to be between 40-70 mg/mL and FRAP values was 82.44 mmol/100g, indicative of its ferric reducing antioxidant power. These result show that complex C5 (-CH3 derivative) was found more potential as antimicrobial and antioxidant agent. Novelty : The coordination of metal complex with enrofloxacin (antibiotic) draws a scheme for the synthesis of new drug as well as increasing the activity of enrofloxacin that is currently in use. Current work supports that the activity of antibiotics could be increased by coordination of metal ion complex. There could be a possibility that these complexes allow to reduce the dose of drug introduced into the body.

Keywords: Dicumarol; Antimicrobial; Antioxidant; Thermal Analysis; TGA

References

Mohamed AA, Ahmed FM, Zordok WA, El-Shwiniy WH, Sadeek SA, Elshafie HS. Novel Enrofloxacin Schiff Base Metal Complexes: Synthesis, Spectroscopic Characterization, Computational Simulation and Antimicrobial Investigation against Some Food and Phyto-Pathogens. Inorganics. 2022;10(11):177. Available from: https://doi.org/10.3390/inorganics10110177
Claudel M, Schwarte JV, Fromm KM. New Antimicrobial Strategies Based on Metal Complexes. Chemistry. 2020;2(4):849–899. Available from: https://doi.org/10.3390/chemistry2040056
Mohamed BA, Hartmann N, Tirilomis P, Sekeres K, Li W, Neef S, et al. Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression. Science Translational Medicine. 2018;10(458). Available from: https://doi.org/10.1126/scitranslmed.aan0724
Lina S, Saba A, Azhar AG. Synthesis and Identification of Some Metal Complexes Derived from Azo Ligand of 4,4'-Methylenedianiline and 4-Bromoaniline and Antimicrobial Studies. Journal of Medicinal and Chemical Sciences. 2023;6:720–732. Available from: https://doi.org/10.26655/JMCHEMSCI.2023.4.3
Kolos NN, Komykhov SA. Contributions by Professor V. D. Orlov to the chemistry of nitrogen heterocycles. Chemistry of Heterocyclic Compounds. 2019;55(4-5):312–323. Available from: https://doi.org/10.1007/s10593-019-02460-2
Subin KK, Aravindakshan KK. Synthesis, cytotoxic, anticancer and antimicrobial activities of some metal complexes of a novel tetradentate Schiff base ligand. Result in chemistry. 2021;3(2):1079–1086. Available from: https://doi.org/10.1016/j.rechem.2021.100129
Patel KS, Patel JC, Dholariya HR, Patel KD. Multiple heating rate kinetic parameters, thermal, X-ray diffraction studies of newly synthesized octahedral copper complexes based on bromo-coumarins along with their antioxidant, anti-tubercular and antimicrobial activity evaluation. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2012;96:468–479. Available from: https://doi.org/10.1016/j.saa.2012.05.057
Uddin MN, Ahmed SS, Alam SMR. REVIEW: Biomedical applications of Schiff base metal complexes. Journal of Coordination Chemistry. 2020;73(23):3109–3149. Available from: https://doi.org/10.1080/00958972.2020.1854745
Vogel AI. Textbook of Practical Organic Chemistry. London. Longman. 1989.
Angelusiu MV, Barbuceanu SFF, Draghici C, Almajan GL. New Cu(II), Co(II), Ni(II) complexes with aroyl-hydrazone based ligand. Synthesis, spectroscopic characterization and in vitro antibacterial evaluation. European Journal of Medicinal Chemistry. 2010;45(5):2055–2062. Available from: https://doi.org/10.1016/j.ejmech.2010.01.033
Mostafa KR, Desoky A, Nabawia MM, Abdo MA, M. Synthesis, characterization, anti-fungi and anti-bacterial activity of new [(2-pyridyl)-3-isatin]-bishydrazone. Russian Journal of General Chemistry. 2013;83(2):2406–2412. Available from: https://link.springer.com/article/10.1134/S1070363213120360
Jani DH, Patel HS, Keharia H, Modi CK. Novel drug-based Fe(III) heterochelates: synthetic, spectroscopic, thermal and<i>in-vitro</i>antibacterial significance. Applied Organometallic Chemistry. 2009;24. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1002/aoc.1581
Ahmed AA, Guzzi B, Hadi SA, AA. Synthesis and_Characterization of Divalent Transition Metals Complexes of Schif base derived from o-phenylenediamine and benzoylacetone and related species. Journal of Science and its application. 2007;1(1):79–90. Available from: https://www.semanticscholar.org/paper/Synthesis-And-Characterization-of-Some-Transition-Hakim-Ahmed/0e7dad7616ca8fbdd74ec05ded272968a96f18b6
Olmez H, Arslan F, Icbud H, Synthesis. Characterization and Biological Evaluation: Copper(II) Complexes of Hydroxy coumarins with Ciprofloxacin. Journal of Thermal Analysis and Calorimetry. 2004;76. Available from: https://doi.org/10.1023/b:jtan.000032264.74742.27
Anjaneyula Y, Rao RP. A New Approach to the Synthesis of Cationic, Neutral or Anionic Diarylgold(III) Complexes. 1986. Available from: https://www.tandfonline.com/doi/abs/10.1080/00945718408058267
Dharamaraj N, Viswanathamurthi P, Natarajan K. Ruthenium(II) complexes containing bidentate Schiff bases and their antifungal activity. Transition Metal Chemistry. 2001;26:105–109. Available from: https://link.springer.com/article/10.1023/A:1007132408648
Bacchia A, Carcellia M, Pelagattia P, Pelizzia C, Pelizzia G, Zanib F. Antimicrobial and mutagenic activity of some carbono-and thiocarbonohydrazone ligands and their copper (II), iron (II) and zinc (II) complexes. Journal of Inorganic Biochemistry. 1999;75:45–53. Available from: https://doi.org/10.1016/s0162-0134(99)00045-8
Murukan B, Mohanan K. Synthesis, characterization and antibacterial properties of some trivalent metal complexes with. Journal of Enzyme Inhibition and Medicinal Chemistry. 2007;22(2):65–70. Available from: https://doi.org/10.1080/14756360601027373

Copyright

© 2023 Prajapati & Chaturvedi. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Indian Society for Education and Environment (iSee)