• P-ISSN 0974-6846 E-ISSN 0974-5645

Indian Journal of Science and Technology


Indian Journal of Science and Technology

Year: 2022, Volume: 15, Issue: 44, Pages: 2386-2392

Original Article

A Cross-sectional Assessment of Gwalior Residents’ Reports of Adverse Reactions to the COVID-19 Immunization

Received Date:07 April 2022, Accepted Date:15 August 2022, Published Date:30 November 2022


Objectives: Many people around the world are worried about the safety and adverse effects of the coronavirus SARS CoV2 vaccine. The study’s goal was to document the side effects experienced by Gwalior residents who had received vaccinations. The other objective includes, to evaluate the potential risk factors associated with Covishield and Covaxin vaccination. Methods: Participants who had received one or both doses of any of the provided vaccines were surveyed using a cross-sectional survey (Covaxin, Covishield). The study enrolled 886 people in total. A large majority of those who received the vaccine had never been exposed to SARS CoV2 before (77.2 percent). Covishield (57.6%), followed by Covaxin (42.4%), was the most commonly prescribed medication in the study. Findings: There were several reported side effects following the first dosage of the vaccine, including discomfort at injection site (79.6%), weariness (52.8%), myalgia (36.5%), headache (34.2%), and chills (38.6%). (31.5 percent). Nausea was the most common gastrointestinal adverse effect, with 14.8% of patients reporting it, followed by appetite loss with 8.9% and diarrhea with 8.9%, respectively (5.7 percent). Each of the second doses of immunizations necessitated hospitalization in only one patient. People in Gwalior had higher side effects with the Covishield vaccine than the Covaxin vaccine, according to this research. Novelty: Large sample size and consideration of randomization technique distinguish this work from others. Analysis of Demographic information with GI distress is a newly performed task.

Keywords: Covid19; Vaccine; Side effects; Symptoms; Immunization


  1. Shadmi E, Chen Y, Dourado I, Faran-Perach I, Furler J, Hangoma P, et al. Health equity and COVID-19: global perspectives. International Journal for Equity in Health. 2020;19(104). Available from: https://doi.org/10.1186/s12939-020-01218-z
  2. Khuroo MS, Khuroo MS, Khuroo MS, Sofi AA, Khuroo NS. COVID-19 Vaccines: A Race Against Time in the Middle of Death and Devastation! Journal of Clinical and Experimental Hepatology. 2020;10(6):610–621. Available from: https://doi: 10.1016/j.jceh.2020.06.003
  3. Jones D, Helmreich S. A history of herd immunity. Lancet. 2020;396(10254):810–811. Available from: https://doi: 10.1016/S0140-6736(20)31924-3
  4. Sprent J, King C. COVID-19 vaccine side effects: The positives about feeling bad. Science Immunology. 2021;6(60). Available from: https://doi:10.1126/sciimmunol.abj9256
  5. Riad A, Pokorná A, Attia S, Klugarová J, Koščík M, Klugar M. Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic. Journal of Clinical Medicine. 2021;10(7):1428. Available from: https://doi.org/10.3390/jcm10071428
  6. Kewei X, Yuanyuan L. A-share Stock Reactions to the Approval of COVID-19 Vaccine Clinical Trial: An Event Study Model of Listed Pharmaceutical Firms’ Returns. 2nd International Conference on Economic Management and Model Engineering (ICEMME). 2020;p. 404–407. Available from: https://doi.org/10.1109/ICEMME51517.2020.00086
  7. Chen L, Wang B, Wang Y, Wang X. Exploratory Data Analysis on the Usage of COVID-19 Vaccine. 6th International Symposium on Computer and Information Processing Technology (ISCIPT). 2021;p. 502–506. Available from: https://doi.org/10.1109/ISCIPT53667.2021.00107
  8. Yang X, Sornlertlamvanich V. Public Perception of COVID-19 Vaccine by Tweet Sentiment Analysis. International Electronics Symposium (IES). 2021;p. 151–155. Available from: https://doi.org/10.1109/IES53407.2021.9594036
  9. Scarabaggio P, Carli R, Cavone G, Epicoco N, Dotoli M. Modeling, Estimation, and Optimal Control of Anti-COVID-19 Multi-dose Vaccine Administration. IEEE 17th International Conference on Automation Science and Engineering (CASE). 2021;p. 990–995. Available from: https://doi.org/10.1109/CASE49439.2021.9551418
  10. Jackson EB, Dreyling R, Pappel I. Challenges and Implications of the WHO’s Digital Cross-Border COVID-19 Vaccine Passport Recognition Pilot. Eighth International Conference on eDemocracy & eGovernment (ICEDEG). 2021;p. 88–94. Available from: https://doi.org/10.1109/ICEDEG52154.2021.9530954
  11. Feng-Cai Z, Yu-Hua L, Xu-Hua G, Li-Hua H, Wen-Juan W, Jing-Xin L, et al. Safety, tolerability, and immunogenicity of a recombinan tadenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial. The Lancet. 2020;395(10240):1845–1854. Available from: https://doi.org/10.1016/S0140-6736(20)31208-3
  12. Zhai P, Ding Y, Wu X, Long J, Zhong Y, Li Y. The epidemiology, diagnosis and treatment of COVID-19. International Journal of Antimicrobial Agents. 2020;55(5):105955. Available from: https://doi.org/10.1016/j.ijantimicag.2020.105955
  13. Figueroa‐hurtado E, Ortíz‐farias DL, Sada‐ovalle I, Maldonado‐ortíz SY, Valdivieso‐jiménez JA, Cortes‐telles A. Humoral immune response in healthcare workers after two doses of a <scp>BNT162b2 mRNA</scp> vaccine in Yucatan, Mexico. Respirology Case Reports. 2022;10. Available from: https://doi.org/10.1002/rcr2.920
  14. Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8(4):420–422. Available from: https://doi.org/10.1016/S2213-2600(20)30076-X
  15. Daniel W, Nianshuang W, Kizzmekia C, Goldsmith S, JA, Ching-Lin H, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020;367(6483):1260–1263. Available from: https://doi: 10.1126/science.abb2507


© 2022 Kumar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Indian Society for Education and Environment (iSee)


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