• P-ISSN 0974-6846 E-ISSN 0974-5645

Indian Journal of Science and Technology

Article

Indian Journal of Science and Technology

Year: 2022, Volume: 15, Issue: 23, Pages: 1151-1158

Original Article

Automatic Control of Microfluidic Flow Using Natural H ydrogels

Received Date:11 January 2022, Accepted Date:01 May 2022, Published Date:29 June 2022

Abstract

Objectives: To explore the effectivity of natural hydrogels for controlling the microfluidic flow in smart bandages. Worldwide, several researchers are trying to develop smart bandage having the capabilities of controlled amount of automatic drug flow to the wound, but the complexity of the required mechatronics does not allow the size of the bandage to be easily wearable. Method: The drug flow within the microchannels of the bandage is controlled using easily available hydro sensitive seeds (Plantago ovato and Salvia hispanica L). On placing the seeds within the microchannels, the investigations showed that the water content within the drug is slowly absorbed by the seeds and the flow of drug is restricted within the channel leading to the controlled flow in a small passage of time. Findings: Plantago ovato and Salvia hispanica L. as natural hydrogels show effective control of the flow rate required for smart bandages. The analysis of the results shows that Salvia hispanica L. can efficiently be used for controlling the drug flow within the microchannels and Plantago ovato for absorbing residue within the sink of the bandage. Novelty: The main problem of the smart bandages developed in some of the labs is the complexity of the design used for controlling the drug flow. The novelty of the proposed smart bandage is its low cost design and efficiency of automatic regulating drug flow without the use of complicated electronics.

Keywords: Hydrogels; fluid control; microfluidic; drug reservoir; smart bandage

References

  1. Tang N, Zheng Y, Jiang X, Zhou C, Jin H, Jin K, et al. Wearable Sensors and Systems for Wound Healing-Related pH and Temperature Detection. Micromachines. 2021;12(4):430. Available from: https://doi.org/10.3390/mi12040430
  2. Lu SH, Samandari M, Li C, Li H, Song D, Zhang Y, et al. Multimodal sensing and therapeutic systems for wound healing and management: A review. Sensors and Actuators Reports. 2022;4:100075. Available from: http://dx.doi.org/10.1016/j.snr.2022.100075
  3. Trotsyuk AA, Jiang Y, Niu S, Larson M, Beard E, Saberi A. Plastic and Reconstructive Surgery - Global Open. Ovid Technologies (Wolters Kluwer Health). 2020:74. Available from: http://dx.doi.org/10.1097/01.gox.0000667504.00255.4f
  4. Musgrave CSA, Fang F. Contact Lens Materials: A Materials Science Perspective. Materials. 2019;12(2):261. Available from: http://dx.doi.org/10.3390/ma12020261
  5. Elkhoury K, Morsink M, Sanchez-Gonzalez L, Kahn C, Tamayol A, Arab-Tehrany E. Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications. Bioactive Materials. 2021;6(11):3904–3923. Available from: http://dx.doi.org/10.1016/j.bioactmat.2021.03.040
  6. Sikdar P, Uddin MM, Dip TM, Islam S, Hoque MS, Dhar AK, et al. Recent advances in the synthesis of smart hydrogels. Materials Advances. 2(14):4532–4573. Available from: http://dx.doi.org/10.1039/d1ma00193k
  7. Jaitpal S, Paul D. Flow Control in Paper-Based Microfluidic Devices. In: Advanced Functional Materials and Sensors. (pp. 47-66) Springer Singapore. 2019.
  8. Bashir S, Hina M, Iqbal J, Rajpar AH, Mujtaba MA, Alghamdi NA, et al. Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications. Polymers. 2020;12(11):2702. Available from: http://dx.doi.org/10.3390/polym12112702
  9. Li C, Obireddy SR, Lai WF. Preparation and use of nanogels as carriers of drugs. Drug Delivery. 2021;28(1):1594–1602. Available from: http://dx.doi.org/10.1080/10717544.2021.1955042
  10. Suhail M, Rosenholm JM, Minhas MU, Badshah SF, Naeem A, Khan KU, et al. Nanogels as drug-delivery systems: a comprehensive overview. Therapeutic Delivery. 2019;10(11):697–717. Available from: http://dx.doi.org/10.4155/tde-2019-0010
  11. Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R. Engineering precision nanoparticles for drug delivery. Nature Reviews Drug Discovery. 2021;20(2):101–124. Available from: http://dx.doi.org/10.1038/s41573-020-0090-8
  12. Lynch CR, Kondiah PPD, Choonara YE, Toit LCD, Ally N, Pillay VN. Hydrogel Biomaterials for Application in Ocular Drug Delivery. Frontiers in Bioengineering and Biotechnology. 2020;8. Available from: http://dx.doi.org/10.3389/fbioe.2020.00228
  13. Franco P, Marco ID. Contact Lenses as Ophthalmic Drug Delivery Systems: A Review. Polymers. 2021;13(7):1102. Available from: http://dx.doi.org/10.3390/ polym13071102
  14. Okur ME, Karantas ID, Şenyiğit Z, Okur NÜ, Siafaka PI. Recent trends on wound management: New therapeutic choices based on polymeric carriers. Asian Journal of Pharmaceutical Sciences. 2020;15(6):661–684. Available from: http://dx.doi.org/10.1016/j.ajps.2019.11.008
  15. Wang W, Lu KJ, Yu CH, Huang QL, Du YZ. Nano-drug delivery systems in wound treatment and skin regeneration. Journal of Nanobiotechnology. 2019;17(1). Available from: http://dx.doi.org/10.1186/s12951-019-0514-y
  16. Ghiuță I, Cristea D. Silver nanoparticles for delivery purposes. Nanoengineered Biomaterials for Advanced Drug Delivery. 2020;p. 347–371. Available from: http://dx.doi.org/10.1016/b978-0-08-102985-5.00015-2
  17. Song J, Zhang Y, Chan SY, Du Z, Yan Y, Wang T, et al. Hydrogel-based flexible materials for diabetes diagnosis, treatment, and management. npj Flexible Electronics. 2021;5(1):26. Available from: https://doi.org/10.1038/s41528-021-00122-y
  18. Correa S, Grosskopf AK, Hernandez HL, Chan D, Yu AC, Stapleton LM, et al. Translational Applications of Hydrogels. Chemical Reviews. 2021;121(18):11385–11457. Available from: http://dx.doi.org/10.1021/acs.chemrev.0c01177
  19. Liu J, Qu S, Suo Z, Yang W. Functional hydrogel coatings. National Science Review. OUP. 2020;8(2). Available from: http://dx.doi.org/10.1093/nsr/nwaa254
  20. Gomes HIO, Martins CSM, Prior JAV. Silver Nanoparticles as Carriers of Anticancer Drugs for Efficient Target Treatment of Cancer Cells. Nanomaterials. 2009;11(4):964. Available from: http://dx.doi.org/10.3390/nano11040964
  21. Mantha S, Pillai S, Khayambashi P, Upadhyay A, Zhang Y, Tao O, et al. Smart Hydrogels in Tissue Engineering and Regenerative Medicine. Materials. 2019;12(20):3323. Available from: http://dx.doi.org/10.3390/ma12203323
  22. Hong Y, Zhou F, Hua Y, Zhang X, Ni C, Pan D, et al. A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds. Nature Communications. 2019;10(1). Available from: http://dx.doi.org/10.1038/s41467-019-10004-7
  23. Morgan RA, Loftus I, Ratnam L, Das R, Mailli L, Hamady MS, et al. Clinical experience with a shape memory polymer peripheral vascular embolisation plug: a case series. CVIR Endovascular. 2021;4(1). Available from: http://dx.doi.org/10.1186/s42155-021-00214-w
  24. Fan F, Saha S, Hanjaya-Putra D. Biomimetic Hydrogels to Promote Wound Healing. Frontiers in Bioengineering and Biotechnology. 2019;9. Available from: http://dx.doi.org/10.3389/fbioe.2021.718377
  25. Pan Z, Ye H, Wu D. Recent advances on polymeric hydrogels as wound dressings. APL Bioengineering. 2021;5(1):011504. Available from: https://doi.org/10.1063/5.0038364
  26. Hong Y, Zhou F, Hua Y, Zhang X, Ni C, Pan D, et al. A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds. Nature Communications. 2019;10(1). Available from: http://dx.doi.org/10.1038/s41467-019-10004-7
  27. Sun X, Zhang Y, Ma C, Yuan Q, Wang X, Wan H, et al. A Review of Recent Advances in Flexible Wearable Sensors for Wound Detection Based on Optical and Electrical Sensing. Biosensors. 12(1):10. Available from: https://doi.org/10.3390/ bios12010010
  28. Beebe DJ, Moore JS, Bauer JM, Yu Q, Liu RH, Devadoss C, et al. Functional hydrogel structures for autonomous flow control inside microfluidic channels. Nature. 2000;404(6778):588–590. doi: 10.1038/35007047
  29. Rajput P, Lehana PK. Design and simulation of microfluidic smart bandage using Comsol Multiphysics. Turkish Journal of Computer and Mathematics Education. 2021;12(5):1650–1662. Available from: https://doi.org/10.17762/turcomat.v12i5.2142
  30. Rajput P, Lehana PK. Fabrication of Smart Bandage Structure. International Journal of Scientific and Technical Advancements. 2020;6(4):111–114.
  31. Rajput P, Khan S, Arya S, Lehana PK. Investigation of nutrient flow through microfluidic channels for medical applications. Journal of Scientific and Technical Advancements. 2015;1(3):113–117.

Copyright

© 2022 Rajput & Lehana. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Published By Indian Society for Education and Environment (iSee)

DON'T MISS OUT!

Subscribe now for latest articles and news.