Clinical Aspects on the Toxicity of Cinnamon Extracts: A Mini Review

K Kalaivani; M R Murali; T N Sathya; Sangeetha V Naveen; T S Kumaravel; S S Murugan

doi:10.17485/IJST/v16i38.TSK

Article

Clinical Aspects on the Toxicity of Cinnamon Extracts: A Mini Review

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Indian Journal of Science and Technology

DOI: 10.17485/IJST/v16i38.TSK

Year: 2023, Volume: 16, Issue: 38, Pages: 3223-3229

Original Article

Clinical Aspects on the Toxicity of Cinnamon Extracts: A Mini Review

K Kalaivani¹, M R Murali¹, T N Sathya¹, Sangeetha V Naveen¹, T S Kumaravel², S S Murugan^3*

¹Regulatory Toxicologist, Department of Toxicology, GLR Laboratories Private Limited, India
²Head, Toxicology and risk assessment and Chairman, GLR Laboratories Private Limited, India
³Principal Toxicologist and Managing Director, GLR Laboratories Private Limited, India

*Corresponding Author
Email: [email protected]

Received Date:19 June 2023, Accepted Date:29 September 2023, Published Date:13 October 2023

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Objective: The current review identifies the adverse and beneficial effects of cinnamon and its components. Method: Literature search using online databases including PubMed, Hindawi, ScienceDirect, ResearchGate, and Elsevier were explored. The keywords used for the literature search included cinnamon, cinnamaldehyde, trans-cinnamaldehyde, cinnamon and stroke, cinnamon and antioxidant, and cinnamon and toxic effects. The inclusion criteria for this review encompassed studies that focused on neuroinflammation and neuroprotection, as well as those that examined the effects of stroke. Additionally, the criteria included studies that investigated experiments on ischemic hemorrhage, encompassing both in vivo and in vitro settings. Findings: The comparative analysis of studies reveals that cinnamon demonstrates potent antioxidant, anticholinergic, and antidiabetic effects. Cinnamaldehyde exhibits inhibitory effects on collagen and thrombin-induced platelet aggregation, as well as collagen-epinephrine-induced acute pulmonary thromboembolism, suggesting its antithrombotic properties. Moreover, transcinnamaldehyde reduces the brain infarct area by downregulating the gene expression of iNOS, COX-2, and TNF-alpha, thus reducing inflammation associated with ischemic stroke. Additionally, the literature review highlights the neuroprotective properties of cinnamon in treating Alzheimer's disease and Parkinson's disease. Consequently, further research is required to elucidate the potential mechanisms through which cinnamon provides neuroprotection and its efficacy in stroke treatment. Novelty: The review reiterates for bioactive compounds present in cinnamon which show promising potential in the treatment of neurodegenerative disorders and stroke.

Keywords: Cinnamon, Trans Cinnamaldehyde, Stroke, Neuroprotection, Anti-oxidant, Anti-inflammation

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© 2023 Kalaivani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Indian Society for Education and Environment (iSee)