• P-ISSN 0974-6846 E-ISSN 0974-5645

Indian Journal of Science and Technology


Indian Journal of Science and Technology

Year: 2023, Volume: 16, Issue: 38, Pages: 3223-3229

Original Article

Clinical Aspects on the Toxicity of Cinnamon Extracts: A Mini Review

Received Date:19 June 2023, Accepted Date:29 September 2023, Published Date:13 October 2023


Objective: The current review identifies the adverse and beneficial effects of cinnamon and its components. Method: Literature search using online databases including PubMed, Hindawi, ScienceDirect, ResearchGate, and Elsevier were explored. The keywords used for the literature search included cinnamon, cinnamaldehyde, trans-cinnamaldehyde, cinnamon and stroke, cinnamon and antioxidant, and cinnamon and toxic effects. The inclusion criteria for this review encompassed studies that focused on neuroinflammation and neuroprotection, as well as those that examined the effects of stroke. Additionally, the criteria included studies that investigated experiments on ischemic hemorrhage, encompassing both in vivo and in vitro settings. Findings: The comparative analysis of studies reveals that cinnamon demonstrates potent antioxidant, anticholinergic, and antidiabetic effects. Cinnamaldehyde exhibits inhibitory effects on collagen and thrombin-induced platelet aggregation, as well as collagen-epinephrine-induced acute pulmonary thromboembolism, suggesting its antithrombotic properties. Moreover, transcinnamaldehyde reduces the brain infarct area by downregulating the gene expression of iNOS, COX-2, and TNF-alpha, thus reducing inflammation associated with ischemic stroke. Additionally, the literature review highlights the neuroprotective properties of cinnamon in treating Alzheimer's disease and Parkinson's disease. Consequently, further research is required to elucidate the potential mechanisms through which cinnamon provides neuroprotection and its efficacy in stroke treatment. Novelty: The review reiterates for bioactive compounds present in cinnamon which show promising potential in the treatment of neurodegenerative disorders and stroke.

Keywords: Cinnamon, Trans Cinnamaldehyde, Stroke, Neuroprotection, Anti-oxidant, Anti-inflammation


  1. Morsi DS, El-Nabi SH, Elmaghraby MA, Ali OAA, Fayad E, Khalifa SAM, et al. Anti-proliferative and immunomodulatory potencies of cinnamon oil on Ehrlich ascites carcinoma bearing mice. Scientific Reports. 2022;12(1):11839. Available from: https://doi.org/10.1038/s41598-022-14770-1
  2. Vijayakumar K, Rengarajan RL, Suganthi N, Prasanna B, Velayuthaprabhu S, Shenbagam M, et al. Acute toxicity studies and protective effects of Cinnamon cassia bark extract in streptozotocin-induced diabetic rats. Drug and Chemical Toxicology. 2022;45(5):2086–2096. Available from: https://doi.org/10.1080/01480545.2021.1907908
  3. Adarsh A, Chettiyar B, Kanthesh BM, Raghu N. Phytochemical screening and antimicrobial activity of Cinnamon zeylanicum. International Journal of Pharmaceutical Research and Innovation. 2020;(13) 22–33. Available from: https://doi.org/10.13140/RG.2.2.33937.04962
  4. Singh G, Maurya S, Delampasona MP, Catalan CAN. A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents. Food and Chemical Toxicology. 2007;45(9):1650–1661. Available from: https://doi.org/10.1016/j.fct.2007.02.031
  5. Tung YT, Chua MT, Wang SY, Chang ST. Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs. Bioresource Technology. 2008;99(9):3908–3913. Available from: https://doi.org/10.1016/j.biortech.2007.07.050
  6. Roussel AM, Hininger I, Benaraba R, Ziegenfuss TN, Anderson RA. Antioxidant Effects of a Cinnamon Extract in People with Impaired Fasting Glucose That Are Overweight or Obese. Journal of the American College of Nutrition. 2009;28(1):16–21. Available from: https://doi.org/10.1080/07315724.2009.10719756
  7. Sharma UK, Kumar R, Ganguly R, Gupta A, Sharmaand AK, Pandey AK. Cinnamaldehyde, An active Component of Cinnamon provides Protection against Food colour induced Oxidative stress and Hepatotoxicity in albino Wistar rats. Vegetos- An International Journal of Plant Research. 2018;31(2):123. Available from: https://doi.org/10.5958/2229-4473.2018.00063.0
  8. Sharma UK, Kumar R, Gupta A, Ganguly R, Pandey AK. Renoprotective effect of cinnamaldehyde in food color induced toxicity. 3 Biotech. 2018;8(4):212. Available from: https://doi.org/10.1007/s13205-018-1241-z
  9. Matsuda H, Matsuda R, Fukuda S, Shiomoto H, Kubo M. Anti-thrombic actions of 70% methanolic extract and cinnamic aldehyde from Cinnamomi Cortex. Chemical and Pharmaceutical Bulletin. 1987;35(3):1275–1280. Available from: https://doi.org/10.1248/cpb.35.1275
  10. Takenaga M, Hirai A, Terano T, Tamura Y, Kitagawa H, Yoshida S. In vitro effect of cinnamic aldehyde, a main component of Cinnamomi Cortex, on human platelet aggregation and arachidonic acid metabolism. Journal of Pharmacobio-Dynamics. 1987;10(5):201–208. Available from: https://doi.org/10.1248/bpb1978.10.201
  11. Huang J, Wang S, Luo X, Xie Y, Shi X. Cinnamaldehyde reduction of platelet aggregation and thrombosis in rodents. Thrombosis Research. 2007;119(3):337–342. Available from: https://doi.org/10.1016/j.thromres.2006.03.001
  12. Hossein N, Zahra Z, Abolfazl M, Mahdi S, AK. Effect of Cinnamon zeylanicum essence and distillate on the clotting time. Journal of Medicinal Plants Research. 2013;7(19):1339–1343. Available from: https://doi.org/10.5897/JMPR12.1198
  13. Fu Y, Yang P, Zhao Y, Zhang L, Zhang Z, Dong X, et al. Trans Cinnamaldehyde Inhibits Microglial Activation and Improves Neuronal Survival against Neuroinflammation in BV2 Microglial Cells with Lipopolysaccharide Stimulation. Evidence-Based Complementary and Alternative Medicine. 2017;2017:1–12. Available from: https://doi.org/10.1155/2017/4730878
  14. Ho SC, Chang KS, Chang PW. Inhibition of neuroinflammation by cinnamon and its main components. Food Chemistry. 2013;138(4):2275–2282. Available from: https://doi.org/10.1016/j.foodchem.2012.12.020
  15. Esmaeili F, Zahmatkeshan M, Yousefpoor Y, Alipanah H, Safari E, Osanloo M. Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study. BMC Complementary Medicine and Therapies. 2022;22(1):143. Available from: https://doi.org/10.1186/s12906-022-03619-9
  16. Abeysekera WPKM, Premakumara GAS, Ratnasooriya WD, Abeysekera WKSM. Anti-inflammatory, cytotoxicity and antilipidemic properties: novel bioactivities of true cinnamon (Cinnamomum zeylanicum Blume) leaf. BMC Complementary Medicine and Therapies. 2022;22(1):259. Available from: https://doi.org/10.1186/s12906-022-03728-5
  17. Gu DT, Tung TH, Jiesisibieke ZL, Chien CW, Liu WY. Safety of Cinnamon: An Umbrella Review of Meta-Analyses and Systematic Reviews of Randomized Clinical Trials. Frontiers in Pharmacology. 2022;12. Available from: https://doi.org/10.3389/fphar.2021.790901
  18. Ahmadi A, Naziri M, Fallahpour F, Gholami K, Arabpour J, Pazeshgare F, et al. Therapeutic potential of cinnamon for neurological disorders: A mini-review. Neurology Asia. 2022;27(1):1–17. Available from: http://www.neurology-asia.org/articles/neuroasia-2022-27(1)-001.pdf
  19. Yulug B, Kilic E, Altunay S, Ersavas C, Orhan C, Dalay A, et al. Cinnamon Polyphenol Extract Exerts Neuroprotective Activity in Traumatic Brain Injury in Male Mice. CNS & Neurological Disorders - Drug Targets. 2018;17(6):439–447. Available from: https://doi.org/10.2174/1871527317666180501110918
  20. Bektaolu K, Koyuncuolu P, Demir T, Sucu D, Akakın G, D, et al. Neuroprotective effect of cinnamaldehyde on secondary brain injury after traumatic brain injury in a rat model. World Neurosurgery. 2021;153:392–402. Available from: https://doi.org/10.1016/j.wneu.2021.06.117
  21. Pyo JH, Jeong YK, Yeo S, Lee JH, Jeong MY, Kim SH, et al. Neuroprotective effect of trans-cinnamaldehyde on the 6-hydroxydopamine-induced dopaminergic injury. Biological and Pharmaceutical Bulletin. 2013;36(12). Available from: https://doi.org/10.1248/bpb.b13-00537
  22. Shimada Y, Goto H, Kogure T, Kohta K, Shintani T, Itoh T, et al. Extract prepared from the bark of Cinnamomum cassia Blume prevents glutamate-induced neuronal death in cultured cerebellar granule cells. Phytotherapy Research. 2000;14(6):466–474. Available from: https://doi.org/10.1002/1099-1573(200009)14:6<466::AID-PTR614>3.0.CO;2-Z
  23. Davaatseren M, Jo YJ, Hong GP, Hur HJ, Park S, Choi MJ. Studies on the anti-oxidative function of trans-cinnamaldehyde-included β-cyclodextrin complex. Molecules. 2017;22(12). Available from: https://doi.org/10.3390/molecules22121868
  24. Bae WY, Choi JS, Jeong JW. The neuroprotective effects of cinnamic aldehyde in an mptp mouse model of parkinson's disease. International Journal of Molecular Science. 2018;19(2). Available from: https://doi.org/10.3390/ijms19020551
  25. Youn HS, Lee JK, Choi YJ, Saitoh SI, Miyake K, Hwang DH, et al. Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization. Biochemistry and Pharmacology. 2008;75(2). Available from: https://doi.org/10.1016/j.bcp.2007.08.033
  26. Wang F, Pu C, Zhou P, Wang P, Liang D, Wang Q, et al. Cinnamaldehyde prevents endothelial dysfunction induced by high glucose by activating Nrf2. Cell Physiology and Biochemistry. 2015;36(1):315–339. Available from: https://doi.org/10.1159/000374074
  27. Hajinejad M, Ghaddaripouri M, Dabzadeh M, Forouzanfar F, Sahab-Negah S. Natural cinnamaldehyde and its derivatives ameliorate neuroinflammatory pathways in neurodegenerative diseases. Biomedical Research International. 2020. Available from: https://doi.org/10.1155/2020/1034325
  28. Qin B, Panickar KS, Anderson RA. Cinnamon polyphenols regulate S100β, sirtuins, and neuroactive proteins in rat C6 glioma cells. Nutrition. 2014;30(2):210–217. Available from: https://doi.org/10.1016/j.nut.2013.07.001
  29. Reddy AM, Seo JH, Ryu SY, Kim YS, Kim YS, Min KR, et al. Cinnamaldehyde and 2-methoxycinnamaldehyde as NF-kappaB inhibitors from Cinnamomum cassia. Planta Medica. 2004;70(9). Available from: https://doi.org/10.1055/s-2004-827230
  30. Zhao J, Zhang X, Dong L, Wen Y, Zheng X, Zhang C, et al. Cinnamaldehyde inhibits inflammation and brain damage in a mouse model of permanent cerebral ischaemia. British Journal of Pharmacology. 2015;172(20). Available from: https://doi.org/10.1111/bph.13270


© 2023 Kalaivani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Indian Society for Education and Environment (iSee)


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