Indian Journal of Science and Technology
DOI: 10.17485/IJST/v16i31.1166
Year: 2023, Volume: 16, Issue: 31, Pages: 2431-2440
Original Article
R Sowmya1, V Supriya2*, M Rajkumar3
1Research Scholar, Department of Clinical Nutrition, Sri Ramachandra Faculty of Allied Health Sciences, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India
2Associate Professor, Department of Clinical Nutrition, Sri Ramachandra Faculty of Allied Health Sciences, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India
3Professor, and Head, Department of General Medicine, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India
*Corresponding Author
Email: [email protected]
Received Date:14 May 2023, Accepted Date:12 July 2023, Published Date:16 August 2023
Objectives: Clitoria ternatea, commonly known as Butterfly pea is a perennial leguminous plant that has been used in folklore in the treatment of various diseases and is reported to have antioxidant and antidiabetic properties. This review is an effort to compile a detailed account of the antioxidant and antidiabetic activity of the plant and the possible mechanisms behind it. Method: The related articles were searched using the databases PubMed, Science Direct, and Google Scholar using terms related to the antioxidant, and antidiabetic activity of C.ternatea such as anthocyanins, ternatins, and hypoglycemic activity. Findings: Various solvents, namely ethanol, methanol, and chloroform, have been commonly employed for extraction but ethanol extraction consistently demonstrated superior efficiency; however, the choice of a specific solvent should be based on its intended purpose. The assessment of free radical scavenging ability predominantly involved the utilization of the DPPH method. Interestingly, the methanol extract displayed a significantly low IC50 value (95.30 mg/ml), indicating a remarkable antioxidant potential in comparison to the other extracts. The antidiabetic effect was evaluated through the measurement of blood glucose, glycated hemoglobin and insulin levels, and the regeneration of pancreatic cells. In most studies, glibenclamide was employed as the benchmark for comparison. Notably, when diabetic rats were administered the chloroform extract at a dose of 300mg/kg body weight, a remarkable reduction in blood glucose levels was observed, decreasing from 378.33 mg/dl to 136.33 mg/dl after 12 days of treatment. Novelty: The novelty of this study lies in its comprehensive approach to understanding the antioxidant and antidiabetic activity of C. ternatea. Unlike previous studies that primarily examine the overall pharmacological properties of the plant, this review focuses specifically on compiling a detailed account of how C. ternatea and its phytoconstituents combat oxidative stress and contribute tothe management of chronic diseases, particularly diabetes.
Keywords: Antidiabetic Activity; Antioxidant; Bioactive Compounds; Clitoria Ternatea; Oxidative Stress
© 2023 Sowmya et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Indian Society for Education and Environment (iSee)
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