• P-ISSN 0974-6846 E-ISSN 0974-5645

Indian Journal of Science and Technology


Indian Journal of Science and Technology

Year: 2022, Volume: 15, Issue: 42, Pages: 2240-2251

Review Article

Diagnostic Tools for COVID-19

Received Date:13 June 2021, Accepted Date:25 September 2022, Published Date:14 November 2022


Objective: To review the current diagnostic methodology available for the Coronavirus Disease 2019 (COVID-19) caused by new Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Method: This review critically analyses the merits and limitations of the recent COVID-19 diagnostics being used for disease prophylaxis and its mitigation. Multiple research papers from 2019- 2022 were consulted. Many novel diagnostics have been included, such as LAMP, CRISPR, AI and other POC techniques, along with conventional RTPCR and CT -SCAN. These have been compared based on principle, protocol, sensitivity, specificity, cost-effectiveness and their pros and cons. Findings: Mass Spectrometry and Loop mediated isothermal amplification (LAMP) were seen to be the most sensitive and specific. They were also very rapid. However, Mass Spectrometry is expensive, as it requires sophisticated instrumentation. LAMP on the other hand, does not require expensive machinery, and thus is a better choice. Novelty: This review has covered most of the techniques, which were not earlier covered in reviews. We have compiled all data in one manuscript for the ease of readers. We have also talked about the diagnostic protocols made in India and compared their sensitivities and specificities.

Keywords: COVID-19; Diagnostics; Coronavirus; Pandemic; Vaccine; Therapeutic


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© 2022 Sehgal et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Indian Society for Education and Environment (iSee)


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