• P-ISSN 0974-6846 E-ISSN 0974-5645

Indian Journal of Science and Technology

Article

Effect of Anti-Diabetic Drugs on Vitamin B12 and Mineral Levels and their Role in Inflammation in type II Diabetes Mellitus (T2DM)
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Indian Journal of Science and Technology

DOI: 10.17485/IJST/v15i24.506

Year: 2022, Volume: 15, Issue: 24, Pages: 1173-1179

Original Article

Effect of Anti-Diabetic Drugs on Vitamin B12 and Mineral Levels and their Role in Inflammation in type II Diabetes Mellitus (T2DM)

Kanchi Divya1*, Rajendran Kannan2, Ramesh Bangariahgari3, Rajesh Bangariahgari3, Raj Kiran Reddy Banala4

1Tutor, Apollo institute of medical sciences and research, Telangana, Hyderabad, India
2Professor& Dean, Medicine, Saveetha medical hospital, Chennai, India
3Arundhati institute of medical sciences, Hyderabad, India
4Sunshine hospitals, Hyderabad, India

*Corresponding Author
Email: [email protected]

Received Date:17 March 2022, Accepted Date:13 April 2022, Published Date:01 July 2022

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Objectives: The purpose of the present study is to know the association between antidiabetic drugs and serum B12, and minerals like calcium, phosphorus, magnesium and zinc to understand their role in inflammation in type 2 diabetes mellitus. Methods: The sample size is 500 blood samples of both genders which was divided into 3 groups: A, B, and C. Group A on metformin of daily dosage 500mg consisted of 200 subjects, Group B on other anti-diabetic drugs of daily dosage 2 mg consisted of 200 subjects. Both groups A and B had no other complications from diabetes. Group C included controls, consisting of 100 healthy individuals with no history of diabetes. Findings: When compared between two drug(metformin and sulfonylureas) groups, the percentages of Serum B12, calcium, phosphorus, magnesium and zinc in both male and female groups were significantly decreased and consequently, inflammatory markers like leptin, IL-6, hsCRP, TNF-a were significantly increased in metformin group rather than who were on metformin and other associated drug group. Novelty : Decreased serum B12 levels in type 2 diabetes mellitus who are on metformin drug represents the potential trigger for inflammatory process which leads to micro and macrovascular complications when compared to sulfonylurea drug group.

Keywords: Diabetes mellitus; Cobalamine; Calciumdependent process; Antioxidants; Inflammatory process

References

  1. Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Research and Clinical Practice. 2022;183:109119. doi: 10.1016/j.diabres.2021.109119
  2. Williams R, Karuranga S, Malanda B. Global and regional estimates and projections of diabetes-related health expenditure. Diabetes Research and Clinical Practice. 2020;162:108072. doi: 10.1016/j.diabres.2020.108072
  3. Harding JL, Pavkov ME, Magliano DJ, Shaw JE, Gregg EW. Global Trends in Diabetes Complications. Diabetologia. 2019(1):3–16. doi: 10.1007/s00125-018-4711-2
  4. Vacurova E, Trnovska J, Svoboda P, Skop V, Novosadova V, Reguera DP, et al. Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice. Nature Communications. 2022;13(1):1866. doi: 10.1038/s41467-022-29486
  6. Oh J. Dietary total, animal, vegetable calcium and type 2 diabetes incidence among Korean adults. Nutrition, Metabolism & Cardiovascular Diseases. 2017;p. 27. doi: 10.1016/j.numecd.2017.10.005
  7. Dahlén AD, Dashi G, Maslov I, Attwood MM, Jonsson J, Trukhan V, et al. Trends in Antidiabetic Drug Discovery: FDA Approved Drugs, New Drugs in Clinical Trials and Global Sales. Frontiers in Pharmacology. 2022;12. doi: 10.3389/fphar.2021.807548
  8. Al-Maskari MY, Waly MI, Ali A, Al-Shuaibi YS, Ouhtit AS. Folate and vitamin B12 deficiency and hyperhomocysteinemia promote oxidative stress in adult type 2 diabetes. Nutrition. 2012;28(7-8):e23–e26. doi: 10.1016/j.nut.2012.01.005
  9. Mo D, Song, Liu HM, Tian Y, Ren. Effects of acarbose and metformin on the inflammatory state in newly diagnosed type 2 diabetes patients. Drug Design, Development and Therapy. 2009;13:2769–2776. doi: 10.2147/DDDT.S208327
  10. Upadhyay J, Polyzos SA, Perakakis N, Thakkar B, Paschou SA, Katsiki N, et al. Pharmacotherapy of type 2 diabetes: An update. Metabolism. 2018;78:13–42. doi: 10.1016/j.metabol.2017.08.010
  11. Bauman WA, Shaw S, Jayatilleke A, Spungen AM, Herbert V. Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care. 2000;23:1227–1258. doi: 10.2337/diacare.23.9.1227
  12. Guerreiro V, Maia I, Neves JS, Salazar D, Ferreira MJ, Mendonça F, et al. Adequate magnesium level as an associated factor of pre-diabetes and diabetes mellitus remission in patients with obesity submitted to bariatric surgery. Scientific Reports. 2021;11(1):21223. doi: 10.1038/s41598-021-00584-0
  13. Pasupuleti VR, Arigela CS, Gan SH, Salam SKN, Krishnan KT, Rahman NA, et al. A Review on Oxidative Stress, Diabetic Complications, and the Roles of Honey Polyphenols. Oxidative Medicine and Cellular Longevity. 2020;2020:1–16. doi: 10.1155/2020/8878172
  15. Elimam H, AMA, IMT. Inflammatory markers and control of type 2 diabetes mellitus. Diabetes and Metabolic Syndrome. 2019;13:800–804. doi: 10.1016/j.dsx.2018.11.061
  16. Yu L, Liu Y, Jin Y, Liu T, Wang W, Lu X, et al. Zinc Supplementation Prevented Type 2 Diabetes-Induced Liver Injury Mediated by the Nrf2-MT Antioxidative Pathway. Journal of Diabetes Research. 2021;2021:1–14. doi: 10.1155/2021/6662418

Copyright

© 2022 Divya et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Published By Indian Society for Education and Environment (iSee)

  • 01 July 2022

Year: 2022, Volume: 15, Issue: 24

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