• P-ISSN 0974-6846 E-ISSN 0974-5645

Indian Journal of Science and Technology


Indian Journal of Science and Technology

Year: 2012, Volume: 5, Issue: 4, Pages: 1-5

Original Article

Effect of Doxorubicin on the morphology, histology and karyology of male reproductive system of white mice, Mus musculus


Doxorubicin (adriamycin) an anti tumour antibiotic is effective against solid and non- solid malignant tumour. It is known to produce reproductive toxicity. An attempt has been made to study the effect of Doxorubicin on the histological and morphometric changes in the male reproductive system and karyological changes in the bone marrow of mice, Mus musculus at the prescribed dosage of 0.5-1 mg/ kg body weight. The histological observations in the present studies showed no apparent damage to the testis and there was no difference in spermatogonial, spermatocyte or spermatid population. Epididymis and the seminal vesicle too showed no apparent damage in the dosage studied. Chromosome analysis of the bone marrow cells did not show any significant aberrations. At the dose designed in the present investigation all the changes observed were transitory and did not impair the normal functioning of the reproductive tissues.
Keywords. Doxorubicin, histology, testis, morphometry , karyology


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