• P-ISSN 0974-6846 E-ISSN 0974-5645

Indian Journal of Science and Technology


Indian Journal of Science and Technology

Year: 2023, Volume: 16, Issue: Special Issue 1, Pages: 1-9

Original Article

Exploration of the Mizo Traditional Medicine: Pharmacognostic Studies of the Indigenous Medicinal Plant, Erythrina stricta

Received Date:23 January 2023, Accepted Date:09 June 2023, Published Date:30 July 2023


Objectives: The study aimed to understand the range of medicinal applications of Erythrina stricta Roxb. (Fabaceae) among the Mizo people of India, and to analyse the pharmacological properties of the bark extract. Methods: Ethnomedicinal investigation was conducted among traditional healers and users. The petroleum ether extract of the bark was analysed for its phytochemical components. Antioxidant property was evaluated by DPPH (2,2- diphenyl-1-picrylhydrazyl) radical scavenging assay. Total antioxidant capacity, flavonoid and total phenolic contents of the plant extract were assessed by using the phosphomolybdate method, Folin-Ciocalteu assay and aluminium chloride assay respectively. Antimicrobial activity was tested on two Gramnegative and four Gram-positive bacteria. Findings: E. stricta was used for the treatment of stomach ulcer, diabetic blisters, intestinal roundworm infection, skin infection, sores and wounds. The plant extract contained phytochemicals like alkaloids, flavonoids, phenols, tannins, amino acids and proteins, phytosterols and triterpenoids. The extract showed concentrationdependent antioxidant activity against DPPH; showing an IC50 value of 3.330.024 mg/ml compared to 0.230.095 mg/ml for the reference butylated hydroxytoluene. The total antioxidant capacity was 12.010.33 mg ascorbic acid equivalent per gram (AAE/g) of the dry extract; the total phenolic content was 3.770.12 mg gallic acid equivalent per gram (GAE/g) of the dry extract; while the total flavonoid content was 7.751.13 mg quercetin equivalent per gram (QE/g) of the dry extract. The extract effectively inhibited the growth of two Gram-positive bacteria, Bacillus cereus and Staphylococcus aureus, and one Gram-negative species, Klebsiella pneumoniae. Novelty: E. stricta was found to have important medicinal applications and pharmacological potential, and needs systematic conservation and propagation. It showed high antioxidant values, and species-specific antibacterial activities.

Keywords: Erythrina stricta; antioxidant activity; antibacterial activity; medicinal plant; phytochemical


  1. Son NT, Elshamy AI. Flavonoids and other Non-alkaloidal Constituents of Genus Erythrina: Phytochemical Review. Combinatorial Chemistry & High Throughput Screening. 2021;24(1):20–58. Available from: https://doi.org/10.2174/1386207323666200609141517
  2. Li F, Bi D, Liang X, Luo R, Zhuang H, Wang L. Alkaloids from the stem barks of Erythrina stricta. Phytochemistry. 2020;170:112220. Available from: https://doi.org/10.1016/j.phytochem.2019.112220
  3. Jiménez-Cabrera T, Bautista M, Velázquez-González C, Jaramillo-Morales OA, Guerrero-Solano JA, Urrutia-Hernández TA, et al. Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain? International Journal of Molecular Sciences. 2021;22(1):1–19. Available from: https://doi.org/10.3390/ijms22010248
  4. Rambo DF, Biegelmeyer R, Toson NSB, Dresch RR, Moreno PRH, Henriques AT. The genus Erythrina L.: A review on its alkaloids, preclinical, and clinical studies. Phytotherapy Research. 2019;33(5):1258–1276. Available from: https://doi.org/10.1002/ptr.6321
  5. Dunai A, Spohn R, Farkas Z, Lázár V, Györkei Á, Apjok G, et al. Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion. eLife. 2019;8(e47088):1–20. Available from: https://doi.org/10.7554/eLife.47088
  6. Álvarez-Martínez FJ, Barrajón-Catalán E, Herranz-López M, Micol V. Antibacterial plant compounds, extracts and essential oils: An updated review on their effects and putative mechanisms of action. Phytomedicine. 2021;90:1–16. Available from: https://doi.org/10.1016/j.phymed.2021.153626
  7. Tiwari P, Khare T, Shriram V, Bae H, Kumar V. Plant synthetic biology for producing potent phyto-antimicrobials to combat antimicrobial resistance. Biotechnology Advances. 2021;48:107729. Available from: https://doi.org/10.1016/j.biotechadv.2021.107729
  8. Vaou N, Stavropoulou E, Voidarou C, Tsigalou C, Bezirtzoglou E. Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives. Microorganisms. 2021;9(10):1–28. Available from: https://doi.org/10.3390/microorganisms9102041
  9. Shaikh JR, Patil MK. Qualitative tests for preliminary phytochemical screening: An overview. International Journal of Chemical Studies. 2020;8(2):603–608. Available from: https://doi.org/10.22271/chemi.2020.v8.i2i.8834
  10. Danish P, Ali Q, Hafeez MM, Malik A. Antifungal and Antibacterial Activity of Aloe Vera Plant Extract. Biological and Clinical Sciences Research Journal. 2020;2020(1). Available from: https://doi.org/10.54112/bcsrj.v2020i1.4
  11. Hossain A, Hossain A, Mannan SJ. Evaluation of antioxidant and analgesic activities of three medicinal plants. Pharmacognosy Research. 2019;11(3):248–253. Available from: https://dx.doi.org/10.4103/pr.pr_164_18
  12. Murthy HN, Joseph KS, Gaonkar AA, Payamalle S. Evaluation of Chemical Composition and Antioxidant Activity of Cordia myxa Fruit Pulp. Journal of Herbs, Spices & Medicinal Plants. 2019;25(3):192–201. Available from: https://doi.org/10.1080/10496475.2019.1585399
  13. Mashuni, Hamid FH, Muzuni, Kadidae LO, Jahiding M, Ahmad LO, et al. The determination of total phenolic content of cocoa pod husk based on microwave-assisted extraction method. In: AIP Conference Proceedings, The 8th International Conference of the Indonesian Chemical Society (ICICS) 2019. Bogor, Indonesia, 6–7 August 2019. AIP Publishing. 2243:030013-1–030013-10.
  14. Anand U, Jacobo-Herrera N, Altemimi A, Lakhssassi N. A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery. Metabolites. 2019;9(11):1–13. Available from: https://doi.org/10.3390/metabo9110258
  15. Huang W, Wang Y, Tian W, Cui X, Tu P, Li J, et al. Biosynthesis Investigations of Terpenoid, Alkaloid, and Flavonoid Antimicrobial Agents Derived from Medicinal Plants. Antibiotics. 2022;11:1–32. Available from: https://doi.org/10.3390/antibiotics11101380
  16. Gulcin İ. Antioxidants and antioxidant methods: an updated overview. Archives of Toxicology. 2020;94:651–715. Available from: https://doi.org/10.1007/s00204-020-02689-3
  17. Maisuthisakul P, Suttajit M, Pongsawatmanit R. Assessment of phenolic content and free radical-scavenging capacity of some Thai indigenous plants. Food Chemistry. 2007;100(4):1409–1418. Available from: https://doi.org/10.1016/j.foodchem.2005.11.032
  18. Wintola OA, Afolayan AJ. Phytochemical constituents and antioxidant activities of the whole leaf extract of Aloe ferox Mill. Pharmacognosy Magazine. 2011;7(28):325–333. Available from: https://doi.org/10.4103/0973-1296.90414
  19. Uddin TM, Chakraborty AJ, Khusro A, Zidan BRM, Mitra S, Emran TB, et al. Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects. Journal of Infection and Public Health. 2021;14(12):1750–1766. Available from: https://doi.org/10.1016/j.jiph.2021.10.020
  20. Vaou N, Stavropoulou E, Voidarou C, Tsigalou C, Bezirtzoglou E. Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives. Microorganisms. 2021;9(10):1–28. Available from: https://doi.org/10.3390/microorganisms9102041
  21. Chen K, Wu W, Hou X, Yang Q, Li Z. A review: antimicrobial properties of several medicinal plants widely used in Traditional Chinese Medicine. Food Quality and Safety. 2021;5:1–22. Available from: https://doi.org/10.1093/fqsafe/fyab020


© 2023 Lalawmpuii et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Indian Society for Education and Environment (iSee)


Subscribe now for latest articles and news.