• P-ISSN 0974-6846 E-ISSN 0974-5645

Indian Journal of Science and Technology


Indian Journal of Science and Technology

Year: 2023, Volume: 16, Issue: 42, Pages: 3721-3726

Original Article

In Vitro Evaluation of Antifungal Activity of Synthesized Novel Zn(II) Complex with Schiff base Ligand

Received Date:19 February 2023, Accepted Date:11 September 2023, Published Date:12 November 2023


Objectives : The current study is concerned with creating a Zn(II) complex with a novel schiff base ligand and to evaluate the Zn(II) metal complex's in-vitro antifungal efficacy against Candida albicans, Candida glabrata, Candida krusei, and Candida tropicali. Methods : N, N’-bis(2-hydroxy-3-methoxybenzaldehyde)-2-phenyl-1,3-propanediamine was synthesized by using 2-hydroxy-3-methoxybenzaldehyde and 2-phenyl-1,3-propanediamine. Metal precursor Zn(OAc)2.2H2O react with the ligand to form Zn(II) metal complex. The structure of the synthesis complex was confirmed by elemental analysis i.e. 1H-NMR, IR and MS spectroscopy. Findings : Zn(II) schiff base complexes have unique characteristics and unusual reactivity, which operate as a foundation for the development of complex molecules with potential use in a wide range of applications. One of the most typical fungal infections is candidiasis. The findings suggest that the Zn(II) metal complex could be a promising antifungal agent. Novelty: Characterization and unique properties of the newly synthesized zinc complex and its potential as a novel class of antifungal agent.

Keywords: Schiff Base, N, N'­bis(2­hydroxy­3­methoxybenzaldehyde)­2­phenyl­1, 3­propanediamine, Antifungal, Candidiasis, Candida


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© 2023 Meena et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Indian Society for Education and Environment (iSee)


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