Indian Journal of Science and Technology
Year: 2016, Volume: 9, Issue: Special Issue 1, Pages: 1-5
Nor Suhaila Mohamad Hanapi1 *, Mohd Marsin Sanagi2 , Nor’ashikin Saim1 , Wan Nazihah Wan Ibrahim1 , Nor Ain Jamaludin2 and Nursyamsyila Mat Hadzir1
1 Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia; [email protected]
2 Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia; [email protected]
*Author for correspondence
Nor Suhaila Mohamad Hanapi
Faculty of Applied Sciences
Email: [email protected]
Objectives: Anew micro-extraction technique, termed Ionic Liquid Impregnated Agarose Film Micro-Extraction (IL-AFLPME) was developed for the determination of selected tricyclic antidepressant drugs prior to their determination using High Performance Liquid Chromatography-Ultraviolet Detection (HPLC-UV). Methods/Statistical Analysis: Agarose film impregnated with ionic liquid (1-hexyl-3-methyl-imidazolium hexafluorophosphate) was utilized as supported liquid membrane between donor phase and acceptor phase. Three selected tricyclic drugs namely; imipramine, amitriptyline and chlorpromazine were employed as model compounds. Two important parameters namely, sample pH and extraction time comprehensively optimized while other parameters, stirring speed and acceptor phase volume were kept constant. Findings: Under the optimized IL-AF-LPME conditions, the proposed method provided good linearity with coefficients of determination (r2 ) (0.9972-0.9984) and low Limits Of Detections (LODs) in the range of 0.0872-0.4273 µg L-1. High percentage recoveries were also obtained (89.9-108.2%) for the real samples. Application/Improvements: This developed method was successfully utilized agarose film impregnated ionic liquid as supported ionic liquid membrane to the determination of selected tricycle antidepressants in river water sample.
Keywords: Antidepressants, Ionic Liquid, River Water, Supported Liquid Membrane
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