Studies on adsorption of diphtheria toxoid on aluminium phosphate gel

N  Sivananda   and B  Sundaran

doi:10.17485/ijst/2010/v3i3.19

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Studies on adsorption of diphtheria toxoid on aluminium phosphate gel

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Indian Journal of Science and Technology

DOI: 10.17485/ijst/2010/v3i3.19

Year: 2010, Volume: 3, Issue: 3, Pages: 248-249

Original Article

Studies on adsorption of diphtheria toxoid on aluminium phosphate gel

N. Sivananda^1* and B. Sundaran

¹ Pasteur Institute of India, Coonoor, Nilgiris-643 103 Tamilnadu, India.
[email protected]

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Aluminium compounds are widely used as an adjuvant in Diphtheria, Tetanus, and Pertussis (DPT) group of vaccines. Diphtheria and tetanus toxoids are adsorbed on aluminium phosphate gel and used in the immunization. Generally a plain vaccine is less immunogenic. After adsorption it will have a repositary action. The present study envisages the adsorption rate of diphtheria toxoid on aluminium phosphate gel at different pH (5.0, 6.0, 6.5, 7.0 and 7.5). The main conclusion drawn from the experiments is that the low pH favours high adsorption rate.
Keywords: Diphtheria toxoid; aluminium phosphate gel, adsorption, vaccine.