Indian Journal of Science and Technology

Abstract

Objectives: Identification of Beta-lactam clinically in laboratories is a necessary factor for the recognition of organisms which are antimicrobials resistant. The main aim of this study is to analyse the antibiotic resistance of Extended Spectrum Beta Lactamases (ESBLs) long with its classifications and its various treatments. Methods: Initially, the working principle or synthesis of antibiotics is elaborated using five modes such as the inference based on the cell wall, protein, nucleic acid, metabolic pathway and based on the cell membrane. Then, the antibiotic mechanism along with its types and various classifications are elaborated. Finally, various options for treating the infections which were caused by their ESBL causing bacteria are also identified. Findings: This study proposes a novel framework for analysing the resistance of antibiotic, classifications and the treatment necessary for the ESBLs in detail. Inferences based on the appearance of cell wall, protein, nucleic acid, metabolic pathway and the cell membrane provides the detailed architecture and working principle of the antibiotics. Classifications of ESBLs along with their types and from which bacteria it is derived from are also mentioned. Applications: This study focuses on the antibiotic characteristics ESBLs along with its various classifications, types and the treatments available for the infections occurred. This study can be further used for the identification of various treatment facilities for the infections caused by the ESBLs. Future research can be an analysis of more factors which influences the cause several associated health conditions due to these ESBLs.

Keywords: Antibiotics, Extended-spectrum b-lactamases, Framework, Resistance, Synthesis