Acoustical Studies on Heterocyclic Drugs In 1,4- Dioxane at 303.15 K

Swati Kolhe; Dipak Patil; Avinash Sonar; Jayant Nehete

doi:10.17485/IJST/v15i6.1960

Article

Acoustical Studies on Heterocyclic Drugs In 1,4- Dioxane at 303.15 K

VIEWS 779
PDF 185

Indian Journal of Science and Technology

DOI: 10.17485/IJST/v15i6.1960

Year: 2022, Volume: 15, Issue: 6, Pages: 253-258

Original Article

Acoustical Studies on Heterocyclic Drugs In 1,4- Dioxane at 303.15 K

Swati Kolhe^1*, Dipak Patil¹, Avinash Sonar², Jayant Nehete¹

¹Sardar Vallabhbhai Patel Arts and Science College, Ainpur, Jalgaon (M.S.), India
²V. S. Naik Arts, Commerce and Science College, Raver, Jalgaon (M.S.), India

*Corresponding Author
Email: [email protected]

Received Date:20 October 2021, Accepted Date:21 January 2022, Published Date:20 February 2022

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Objective: Main objective is to study the solute solvent interactions in different heterocyclic drugs with the help of various acoustic properties. Method: The values of ultrasonic velocity are measured by using ultrasonic interferometer for solution of different concentrations of heterocyclic drugs (Lamivudine, Simvastatin) in 70% 1,4-dioxane as a solvent at 303.15 K. This experimental data is used to explore the acoustic properties like as intermolecular free length (Lf ), adiabatic compressibility (b s), apparent molal volume (ϕv), specific acoustic impedance (Z), apparent molal compressibility (ϕk), limiting apparent molal compressibility (ϕ0k ), limiting apparent molal volume (ϕ0v ), relative association (RA), solvation number (Sn) with respect to change in concentration. Finding : It is noticed that the solute solvent interaction between the heterocyclic drugs and dioxane systems are strong. Novelty: Heterocyclic drugs viz. Lamivudine and Simvastatin were used to study different acoustic properties. In present work the acoustic properties of Lamivudine and Simvastatin in 1,4-dioxane at 303.15K have been reported.

Keywords: Lamivudine, Simvastatin, intermolecular free length, apparent molal volume, adiabatic compressibility, ultrasonic velocity.

References

Devi NG, Rao NVNBS, Sirija MR, Ramachandran D. Ultrasonic study on binary liquid mixtures of propiophenone with anilines and alkyl substituted anilines at T=303.15 to 318.15 K. Korean Journal of Chemical Engineering. 2018;35(7):1488–1499. Available from: https://dx.doi.org/10.1007/s11814-018-0053-5
Dhote AB, Bedare GR. Ultrasonic analysis on molecular interactions in Pantoprazole Sodium solution at different concentration. Research Journey. 2019;p. 37.
Thakur A, Juglan KC, Kumar H, Kaur K. Apparent molar properties of glycols in methanol solutions of propyl 4-hydroxybenzoate (propylparaben) at T = (293.15 to 308.15) K: an acoustic and volumetric approach. Physics and Chemistry of Liquids. 2020;58(6):803–819. Available from: https://dx.doi.org/10.1080/00319104.2019.1660980
Chakraborty N, Kaur K, Juglan KC, Kumar H. Volumetric and Ultrasonic Studies on Interactions of Glycols in Aqueous Solutions of Xylitol at Different Temperatures. Journal of Chemical & Engineering Data. 2020;65(4):1435–1446. Available from: https://dx.doi.org/10.1021/acs.jced.9b00869
Meshram YK, Narwade ML. Studies in acoustical properties of some substituted pyrazolines in 70% acetone-water mixture at 300C. Acta Ciencia Indica Chemistry. 2001;27:67–70.
Palani R, Saravanan S. Volumetric, Compressibility and Transport Studies of Some Amino Acids in Aqueous Magnesium Acetate at 298.15K. Research Journal of Physics. 2008;2(1):13–21. Available from: https://dx.doi.org/10.3923/rjp.2008.13.21
Syal VK, Chauhan A, Chauhan S. Ultrasonic velocity, viscosity and density studies of poly (ethylene glycols) (PEG - 8,000, PEG - 20,000) in acetonitrile (AN) and water (H2O) mixtures at 250C. J. Pure Ultrasound. 2005;27:61–69.
Kalyanasundaram S, Sundaresan S, Hemalatha J. Determination of interaction parameter in aqueous Poly (vinylpyrrolidone) solutions. Bulletin of electrochemistry. 1999;15:501.
Alka T, Pravina P, Bichile GK. Studies of acoustic and thermodynamic properties of citric acid in double distilled water at different temperatures. Journal of Chemical and Pharmaceutical Research. 2011;3:165–168.
Mishra AP, Mishra DK. Study of Intermolecular Interaction of some synthesized 3d metal complexes in solution, by ultrasonic velocity measurement. Journal of Chemical and Pharmaceutical Research. 2011;3:489–498.
Arvinthraj M, Venktesan S, Meera D. Acoustical and molecular interaction studies of amide with aliphatic amines in benzene at various temperatures. Journal of Chemical and Pharmaceutical Research. 2011;3(2):623.
Thakur SK, Chauhan S. Ultrasonic Velocity and allied parameters of drug Colimax in aqueous 1-propanol at 298.15K. Journal of Chemical and Pharmaceutical Research. 2011;3(2):657.
Mirikar SA, Pawar PP, Bichile GK. "Ultrasonic Velocity, Density and Viscosity Measurement of Amino Acid in Aqueous Electrolytic Solutions at 308.15K" American Journal of Pharmacology and Pharmacotherapeutics. 2015;02(01):2–7. Available from: https://dx.doi.org/10.21767/2393-8862.100023
Ganjare PJ, Aswale SR, Aswale SS. Prediction of molecular interactions in liquids from density, viscosity, sound velocity and conductance measurements. Vidyabharati International Interdisciplinary Research Journal. 2020.
Kincaid JF, Eyring H. Free Volumes and Free Angle Ratios of Molecules in Liquids. The Journal of Chemical Physics. 1938;6(10):620–629. Available from: https://dx.doi.org/10.1063/1.1750134
Kulkarni SS, Khadke UV. Effect of Solvents on the Ultrasonic Velocity and Acoustic Parameters of Polyvinylidene Fluoride Solutions. Indian Journal of Materials Science. 2016;2016:1–6. Available from: https://dx.doi.org/10.1155/2016/9582582
Agarwal PB, Siddiqui IM, Narwade ML. Acoustic properties of substituted thiadiazoles and methyl-5-carboxylates in dioxan-water, ethanol-water and acetone-water mixtures at 298.5±0.1 K. Indian Journal of Chemistry. 2003;42(5):1050–1052.
Hussain SGM, Kumar R, Ali MMN, Sankar D, Kannappan V. Unravelling the non-covalent interactions in certain n-propyl amine – Ether systems through acoustic and DFT studies at 303.15 K. Journal of Molecular Liquids. 2022;345:117806. Available from: https://dx.doi.org/10.1016/j.molliq.2021.117806
Sonar AN, Pawar NS. Ultrasonic velocity, density and viscosity measurements of substituted heterocyclic drugs in 1,4-Dioxane at 303K. Rasayan Journal of Chemistry. 2010;3(1):38–43.
Sonar AN, Pawar NS. Ultrasonic studies on molecular interactions of substituted heterocyclic drug in dioxane-water mixture at 303K. European Journal of Biomedical and Pharmaceutical Sciences. 2016;p. 349–352.
Sonar AN, Pawar NS. Acoustic and Volumetric Properties of Digoxin and Thiabendazole in 1, 4 Dioxane at 303 K. E-Journal of Chemistry. 2010;7(3):789–794. Available from: https://dx.doi.org/10.1155/2010/760253

Copyright

© 2022 Kolhe et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Published By Indian Society for Education and Environment (iSee)