Antidiabetic Activity of Schizochytrium sp. Against Streptozotocin-Nicotinamide-Induced Diabetes in Rats

S Harshitha; Mayukh Sarkar; G Rachana; H A Harshitha

doi:10.17485/IJST/v16i48.2997

Article

Antidiabetic Activity of Schizochytrium sp. Against Streptozotocin-Nicotinamide-Induced Diabetes in Rats

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Indian Journal of Science and Technology

DOI: 10.17485/IJST/v16i48.2997

Year: 2023, Volume: 16, Issue: 48, Pages: 4743-4751

Original Article

Antidiabetic Activity of Schizochytrium sp. Against Streptozotocin-Nicotinamide-Induced Diabetes in Rats

S Harshitha^1*, Mayukh Sarkar², G Rachana¹, H A Harshitha¹

¹Department of Pharmacology, Rajiv Gandhi University of Health Sciences, Krupanidhi College of Pharmacy, Bengaluru, 560035, Karnataka, India
²Assistant Professor, Department of Pharmacology, Rajiv Gandhi University of Health Sciences, Krupanidhi College of Pharmacy, Bengaluru, 560035, Karnataka, India

*Corresponding Author
Email: [email protected]

Received Date:23 November 2023, Accepted Date:22 December 2023, Published Date:28 December 2023

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Objective: To evaluate the antidiabetic effect of agal oil in Streptozotocin-nicotinamide-induced type 2 diabetes in rats. Methods: Diabetes was induced by a single IP injection of Streptozotocin (50 mg/kg bw) and Nicotinamide (120 mg/kg bw). Daily the algal oil (Schizochytrium sp.) was administered with a single dose of 400 mg/kg bw and 800 mg/kg bw for the period of 21 days. The algal oil effect on body weight, fasting blood sugar, as well as serum lipid profile were evaluated. Histopathological examination of the pancreas was carried out to characterize the changes due to diabetes. Findings: A significant reduction in blood sugar levels was noted with algae oil. After 21 days of treatment of diabetic rats with algal oil in dosages of 400 mg/kg bw as well as 800 mg/kg bw, we noted a marked decrease in the levels of fasting blood glucose, HbA1c, triglycerides, LDL cholesterol as well as total cholesterol. Also, we observed a significant increase in the levels of haemoglobin, HDL cholesterol and body weight when compared to untreated diabetic rats (p < 0.05). These findings provide evidence for antidiabetic as well as anti-obesity properties of algal oil by regulating the parameters of lipid profile. Furthermore, the oral administration of algal oil demonstrated the regeneration of pancreatic beta cells which was evident in the histopathological examinations of pancreatic tissue in diabetic rats. Novelty: Algal oil functions effectively as an antidiabetic agent with less chance of side effects. This study showed the potential benefits of algal oil as a suitable bioactive compound that can be utilized in functional foods as a natural diabetes treatment.

Keywords: Algal oil, Diabetes, Streptozotocin, Nicotinamide, Blood glucose level

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Copyright

© 2023 Harshitha et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Indian Society for Education and Environment (iSee)