Association of rs1800790 in FGB and Endometrium in Iranian Women

P  Zohre Omidi; Mehrdad Hashemi  and Ahmad Ebrahimi

doi:10.17485/ijst/2016/v9i7/87732

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Association of rs1800790 in FGB and Endometrium in Iranian Women

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Indian Journal of Science and Technology

DOI: 10.17485/ijst/2016/v9i7/87732

Year: 2016, Volume: 9, Issue: 7, Pages: 1-4

Original Article

Association of rs1800790 in FGB and Endometrium in Iranian Women

P. Zohre Omidi¹ , Mehrdad Hashemi² and Ahmad Ebrahimi^3*

¹Islamic Azad University, Tehran Medical Sciences Branch,Tehran, Iran;[email protected] ²Molecular Genetics, Islamic Azad University, Tehran Medical Sciences Branch,Tehran, Iran; [email protected] ³Molecular Genetics,The Cellular and Molecular Endocrine, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; [email protected]

*Author for Correspondence
Ahmad Ebrahimi
Molecular Genetics,The Cellular and Molecular Endocrine, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; [email protected]

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background/Objectives: Endometriosis is a disease with the growth of endometrium-like tissue in aberrant locations outside of the uterine.Variants of a number of genes have been associated to endometriosis; however, the contributions of these genetic variants in different ethnic groups are not similar. Methods/Statistical Analysis: Our study isAssociation of rs1800790 in FGB and endometrium in Iranian women. The case–control study included 100 affected patients and 100 controls. The genetic variants on FGB gene was genotyped using Tetra Amplification Refractory Mutation SystemPolymerase Chain Reaction (Tetra-ARMS-PCR).Findings: Association of risk allele with endometriosis was examined using SPSS software. Results showed that FGB gene polymorphism genotype frequencies were compared in the patients and control. Frequency of AA, AG and GG genotypes of the gene polymorphism fibrinogen beta polypeptide chain were28, 48and 24% in patients respectively, and66, 31and 3% in control group respectively. Results showed that relation between patients and control group is significant (P=4.619e-11).Applications/Improvements: This study showed that there was meaningful relationship between FGB gene polymorphism and increased risk of endometriosis in women studied.

Keywords: Endometriosis, FGB Gene, rs1800790, Women