Indian Journal of Science and Technology
Year: 2016, Volume: 9, Issue: 7, Pages: 1-4
P. Zohre Omidi1 , Mehrdad Hashemi2 and Ahmad Ebrahimi3*
1Islamic Azad University, Tehran Medical Sciences Branch,Tehran, Iran;[email protected] 2Molecular Genetics, Islamic Azad University, Tehran Medical Sciences Branch,Tehran, Iran; [email protected] 3Molecular Genetics,The Cellular and Molecular Endocrine, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; [email protected]
*Author for Correspondence
Molecular Genetics,The Cellular and Molecular Endocrine, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; [email protected]
Background/Objectives: Endometriosis is a disease with the growth of endometrium-like tissue in aberrant locations outside of the uterine.Variants of a number of genes have been associated to endometriosis; however, the contributions of these genetic variants in different ethnic groups are not similar. Methods/Statistical Analysis: Our study isAssociation of rs1800790 in FGB and endometrium in Iranian women. The case–control study included 100 affected patients and 100 controls. The genetic variants on FGB gene was genotyped using Tetra Amplification Refractory Mutation SystemPolymerase Chain Reaction (Tetra-ARMS-PCR).Findings: Association of risk allele with endometriosis was examined using SPSS software. Results showed that FGB gene polymorphism genotype frequencies were compared in the patients and control. Frequency of AA, AG and GG genotypes of the gene polymorphism fibrinogen beta polypeptide chain were28, 48and 24% in patients respectively, and66, 31and 3% in control group respectively. Results showed that relation between patients and control group is significant (P=4.619e-11).Applications/Improvements: This study showed that there was meaningful relationship between FGB gene polymorphism and increased risk of endometriosis in women studied.
Keywords: Endometriosis, FGB Gene, rs1800790, Women
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