• P-ISSN 0974-6846 E-ISSN 0974-5645

Indian Journal of Science and Technology


Indian Journal of Science and Technology

Year: 2015, Volume: 8, Issue: Supplementary 8, Pages: 1-10

Original Article

Comparison of Creatine and Glutamine Supplementation Consumption along withResistance Exercise on the Level of Female Mice’ALP


BackgroundandPurpose:In recent years, in order to improve power, speed,the increase in the volume ofthe musculature, preventing sports injuries and maintain the muscle performance athletes use from different resistance exercises and food supplements. In this regard, present study has been conducted with the aim of comparison the influence of an 8 week period consumption of creatine (2 g/kg/day in 1st week and 0.48 g/kg/day during 2nd to 8th weeks) and glutamine (1g/ kg/day from first to eight weeks) along with resistance exercise and weight on the level of ALP of small laboratory female rats. Materials and Methods: This experimental study was done on 80 Small adult female mice of Surrey species (28 ± 5 gram). The animals were randomly divided into 8 main groups of: resistance exercise, resistance exercise + creatine, resistance exercise + glutamine, resistance exercise + glutamine + creatine, creatine, glutamine, creatine + glutamine and control groups (N = 10). Resistance exercise (5 days a week) was including: climbing (4 sets, 5 times repetition with two minutes rest between the sets) from a ladder (with the height of one meter and including 26 steps) and bearing 30 percent of the weight of the Mouse body (hanging from tail) in the first week and the increasing it up to 200 percent of body weight till the last week of the experiment. During 24 hours after the last practice session of resistance exercise, the blood sample was taken and the the level of ALP has been measured. Findings: The results showed that the level of ALP enzyme in groups supplemented with creatine + glutamine (combined with each other) and underwent the resistance exercise had been increased in comparison with the control group (144.3 ± 15.86 in comparison with 234.7 ± 25.69/UL; P < 0.05). Also the results of Duncan test showed that the highest gaining of the weight was related to the group of combination of resistance exercise and glutamine and the lowest was related to the control and creatine, creatine + glutamine and resistance exercise + creatine groups. Conclusion: The results of this research indicate an increase in the level of ALP enzyme in the liver of mice under effect of the resistance exercise and consumption of creatine-glutamine supplementation and it showed that consumption of glutamine supplementation along with resistance exercise has the most influence upon the animals’ weight. Therefore these results suggest more importance of them and more studies are necessary to be done. 
Keywords: ALP Enzyme, Creatine, Glutamine, Laboratory Mouse, Liver, Resistance Exercise


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