Drug designing for ring finger protein 110 involved in adenocarcinoma (human breast cancer) using casuarinin extracted from Terminalia arjuna

V Brindha; A  Saravanan  and R  Manimekalai

doi:10.17485/ijst/2009/v2i2.10

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Drug designing for ring finger protein 110 involved in adenocarcinoma (human breast cancer) using casuarinin extracted from Terminalia arjuna

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Indian Journal of Science and Technology

DOI: 10.17485/ijst/2009/v2i2.10

Year: 2009, Volume: 2, Issue: 2, Pages: 22-26

Original Article

Drug designing for ring finger protein 110 involved in adenocarcinoma (human breast cancer) using casuarinin extracted from Terminalia arjuna

V.Brindha¹ , A. Saravanan² and R. Manimekalai¹

¹Department of Bioinformatics, Dr. MGR Janaki College, Chennai-28, India.
²Department of Chemical Engineering, Sathyabama University,Chennai-119, India.

*Author for the correspondence:
V.Brindha
Department of Bioinformatics, Dr. MGR Janaki College,
Chennai-28, India.
E-mail: [email protected]

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Breast cancer is the most common malignancy in women. Ring finger protein 110 was involved in the development of oncogenes, which mediate protein-protein interactions and involved in the formation of multi protein complexes. The investigation of this study reveals the modeling of the 3D structure of the protein with the final refinement of -9700.41KJ/Mol. Casuarinin, a hydrolysable tannin isolated from the bark of Terminalia arjuna was investigated for its antiproliferative activity in human breast Adenocarcinoma. The energy value -40.87 Kcal/ mol and the Rms score value -1.00 showed the hydrolysable tannin (Casuarinin) has higher specificity and efficiency towards the target protein ring finger 110.

Keywords: Adenocarcinoma, breast cancer, ring finger protein, Terminalia arjuna, casuarinin.