• P-ISSN 0974-6846 E-ISSN 0974-5645

Indian Journal of Science and Technology


Indian Journal of Science and Technology

Year: 2009, Volume: 2, Issue: 2, Pages: 22-26

Original Article

Drug designing for ring finger protein 110 involved in adenocarcinoma (human breast cancer) using casuarinin extracted from Terminalia arjuna


Breast cancer is the most common malignancy in women. Ring finger protein 110 was involved in the development of oncogenes, which mediate protein-protein interactions and involved in the formation of multi protein complexes. The investigation of this study reveals the modeling of the 3D structure of the protein with the final refinement of -9700.41KJ/Mol. Casuarinin, a hydrolysable tannin isolated from the bark of Terminalia arjuna was investigated for its antiproliferative activity in human breast Adenocarcinoma. The energy value -40.87 Kcal/ mol and the Rms score value -1.00 showed the hydrolysable tannin (Casuarinin) has higher specificity and efficiency towards the target protein ring finger 110.

Keywords: Adenocarcinoma, breast cancer, ring finger protein, Terminalia arjuna, casuarinin.


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