• P-ISSN 0974-6846 E-ISSN 0974-5645

Indian Journal of Science and Technology


Indian Journal of Science and Technology

Year: 2023, Volume: 16, Issue: 40, Pages: 3559-3566

Original Article

Evaluation of Momordica cochinchinensis Fruit Methanolic Extract for Potential Medicinal Use

Received Date:04 April 2023, Accepted Date:19 July 2023, Published Date:31 October 2023


Objectives: This study evaluated the biological and pharmacological activities of Momordica cochinchinensis fruit methanolic extract (MCME). Methods: The extract was analyzed for its phytochemical constituents and tested for toxicity and antimicrobial properties. The hypoglycemic activity was also evaluated in hyperglycemic mice. Findings: The results showed that the extract contained important phytochemical constituents and exhibited antimicrobial activity against S. aureus and E. coli. The extract was found to contain important phytochemical constituents, including saponins, flavonoids, and phenolic compounds. In a brine shrimp toxicity assay, the extract exhibited toxicity activity, with an LC50 mortality rate of 10 μg/mL after 24 hours. Additionally, in hyperglycemic mice, the extract was found to be more efficient in hypoglycemic activity than the positive control, Metformin, with a decrease in blood glucose levels of 64.8% and 54.2%, respectively, after 24 hours of treatment. Nove lty: This study serves as the first unprecedented investigation of the hypoglycemic effect of MCME including novel antibacterial activity against E. coli.

Keywords: Gac fruit, phytochemical analysis, toxicity test, antibacterial activity, hypoglycemic activity


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© 2023 Domingo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Indian Society for Education and Environment (iSee)


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