Indian Journal of Science and Technology

Abstract

Objective: Fusion of heterocyclic ring system of the pentacyclic triterpenoids at position 2 and 3 of the steroidal nucleus has been found to afford chemically useful compounds. Method/Analysis: Lupeol (I) was used as the starting material to carry out a transformative reaction to introducing oxadiazole moiety to ring A of the triterpenoid which was identified as lupan (2,3-C) 1′,2′,5′-oxadiazole (VI). The structures of the compounds were established based on spectroscopic (UV, IR, NMR) analysis. Finding: The derivative of the pentacyclic triterpenoid obtained has been selected for their antibacterial, fungicidal and Phytotoxicity at different concentration with respect to parent compound and found oxadiazole derivative almost at all concentration give better result compare to parent compound. Despite their widespread existence in the vicinity and their direct and indirect defensive activities, systematic study regarding their biocidal activity has not been attempted sufficiently. Since limited chemical work has so far been attempted on pentacyclic triterpene skeleton so there is a possibility of ample opportunity to study the effect of number of reagents on them. Novelty/Importance: These investigations not only enrich the triterpene chemistry but at the same time may yield a number of very useful pharmacologically important derivatives.

Keywords: Biological Activity, Extraction, Phytotoxicity, Triterpenoids, Transformative Reaction