Indian Journal of Science and Technology

Abstract

Hepatocellular Carcinoma (HCC) is the fifth most common cancer which causes thousands of death worldwide and the majority of the HCC sufferers are from Asia. Infection of Hepatitis B Virus and Hepatitis C Virus are major reasons for the development of HCC. The factors which add to its persistence are both environmental and genetic. Asia being a vast continent has a huge diversity of both. Polymorphisms in different genes linked with HCC lead to either increase or decrease in its risk. In this review we have focused on genetic factors responsible for HCC, with a special perspective based on the geography. According to the UN geo-scheme Asia is split into Eastern, Southeastern, Southern, Western and Central Asia. Here we have discussed on various genetic mutations which may or may not be the risk factor for HCC. The maximum HCC linked genetic mutations were observed in the Eastern region especially in China.

Keywords: Asian Population, Genetic Factor, Hepatocellular Carcinoma, Polymorphisms, UN geo-scheme