• P-ISSN 0974-6846 E-ISSN 0974-5645

Indian Journal of Science and Technology


Indian Journal of Science and Technology

Year: 2022, Volume: 15, Issue: 45, Pages: 2482-2491

Original Article

Hepatoprotective Activity of Merremia tridentata against Carbon Tetrachloride Induced Hepatotoxicity in Rats

Received Date:11 June 2022, Accepted Date:22 September 2022, Published Date:07 December 2022


Objectives: Liver performs a variety of function including storage and purification of blood, secretion of bile, synthesis of plasma proteins and drug detoxification. In an attempt to study the biochemical and connective tissue metabolism during the progression of hepatic fibrosis and to gain more insight into the mechanisms leading to the altered metabolic processes in human hepatic fibrosis, an experimental animal model was developed using administration of carbon tetrachloride (CCl4). Methods: The present study evaluates the hepatoprotective activity of Merremia tridentate plant extract against CCl4 induced liver damage in Wistar albino rats. CCl4 caused a rise in liver and serum AST, ALT, ALP, ACP and total Bilirubin content. Pretreatment and post treatment of rats with ethanolic and aqueous extracts (50,100 & 200 mg/kg b.wt) significantly reduced these serum parameters and antioxidant enzymes levels compared to CCl4 induced rats. The post-treatment had better activity than the pre-treatment groups. Findings: Preliminary phytochemical analysis showed the presence of tannins, saponins, flavonoid, alkaloid, anthocyanin, quinones, glycosides, cardiac glycosides, terpinoids, phenol, coumarin and reducing sugar which may be responsible for the hepatoprotective activity. The liver stabilization activity is due to the presence of bioactive compounds in the Merremia tridentate extracts. Conclusions: Thus, Merremia tridenta extracts ameliorated the liver damage caused by the CCl4and raised the liver and serum enzymes to normal levels:

Keywords: Liver; Detoxification; Carbon Tetrachloride; Merremia trident; Hepatotoxins


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© 2022 Manimegalai et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Indian Society for Education and Environment (iSee)


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