Hepatoprotective effects of Cassia tora on CCl4 induced liver damage in albino rats

A  Vetrivel Rajan; N  Shanmugavalli; C  Greety Sunitha  and V  Umashankar

doi:10.17485/ijst/2009/v2i3.17

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Hepatoprotective effects of Cassia tora on CCl4 induced liver damage in albino rats

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Indian Journal of Science and Technology

DOI: 10.17485/ijst/2009/v2i3.17

Year: 2009, Volume: 2, Issue: 3, Pages: 1-4

Original Article

Hepatoprotective effects of Cassia tora on CCl4 induced liver damage in albino rats

A. Vetrivel Rajan¹ , N. Shanmugavalli^2*, C. Greety Sunitha³ and V. Umashankar²

1Biocon India Pvt. Ltd., Bangalore;
2Dept. of Bioinformatics, SRM University, Chennai, India
3PG Dept. of Biochemistry, VHNSN College,Virudhunagar, India

*Author for the correspondence:
N. Shanmugavalli
Dept. of Bioinformatics, SRM University,
Chennai, India
E-mail: [email protected]

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

The objective of the present study is to determine the hepatoprotective effects of Cassia tora against carbon tetra chloride induced liver damage in albino rats. The efficacy of the treatment was estimated by the serum level marker enzymes: serum glutamatic oxaloacetic transaminase, serum glumate pyruvate transaminase and lactate dehydrogenase. The treatment also includes the estimation of enzymatic antioxidants: superoxide dismutase, glutathione peroxidase, glutathione-S transferase and catalase; non-enzymatic antioxidants: vitamin C and vitamin E. The results of this study reveal the remarkable increase of marker enzymes in induced rats and decreased level in cassia torra treated ones. Furthermore, the level of enzymatic and non-enzymatic antioxidant level were elevated in treated rats compared to induced ones.

Keywords: Antioxidants, Cassia tora, CCl4, liver damage, albino rats.