• P-ISSN 0974-6846 E-ISSN 0974-5645

Indian Journal of Science and Technology


Indian Journal of Science and Technology

Year: 2023, Volume: 16, Issue: 3, Pages: 190-203

Original Article

Self-Solidifying and Self-Nanoemulsifying Drug Delivery System of Itraconazole

Received Date:27 September 2022, Accepted Date:19 December 2022, Published Date:23 January 2023


Objective: To improve solubility, dissolution, and permeability of BCS class II drug Itraconazole (ITZ) using a self solidifying self nano emulsifying drug delivery system (SNEDDS). Method: The solubility of ITZ was assessed in oils, surfactants, co-surfactants, and buffers. Surfactants, co-surfactants, and combination of surfactants (S-comb) were selected on the basis of emulsification efficacy test. The ability to solidify self emulsifying mixture was assessed and solid SNEDDSS was developed and optimised. Finding: Solubility of ITZ was found maximum in 0.1N HCl (0.120  0.07mg/mL) followed by SGF (0.089  0.01mg/mL). Out of 20 oils screened, Peceol showed highest solubility. Among all surfactants and co-surfactants studied, Labrafil M 1944 CS (LM 1944) showed highest potential to solubilize ITZ (14.91 mg/g). The globule size of the optimised formulation was found to be 40.11 nm with PDI of 0.144. Zeta potential study revealed the stability of the SNEDDS. Drug content of solid SNEDDS of ITZ was found within the range of 98.11% to 102.51%, which was found in the acceptable limit. It was observed that ITZ solid SNEDDS (SSNEDDS) showed a promising improvement in the in vitro dissolution profile compared to the plain ITZ and marketed product in all three-dissolution media. Nearly 3-fold enhancement of permeability of ITZ was attributed by uniformly dispersed globules with nano size. Analytical characterization demonstrated that the drug and excipients are compatible with amorphous characteristics of the ITZ. Novelty: The developed self solidifying SNEDDS of ITZ showed enhanced solubility, dissolution, and permeability in comparison to the pure drugs (ITZ). Self solidifying SNEDDS would be a novel approach to overcome the limitations associated with liquid dosage forms.

Keywords: Itraconazole; Solubility; Bioavailability; Self Nano Emulsifying Drug Delivery System (SNEDDS); Permeability


  1. Bharti N, Sharma P. Microwave Generated Bio nanocomposites for Solubility and Dissolution Enhancement of Poorly Water-Soluble Drug. Asian Journal of Pharmaceutical Research. 2022;12(3):192–198. Available from: https://doi.org/10.52711/2231-5691.2022.00031
  2. Reddy SM, Baskarla S. A Review on Formulation and Development of Solid Self-Nano Emulsifying Drug Delivery Systems. International Journal of Pharmaceutical Sciences and Nanotechnology. 2021;14(4):5519–5228. Available from: https://doi.org/10.37285/ijpsn.2021.14.4.1
  3. Hanif M, Ameer N, Mahmood MK, Shehzad A, Azeem M, Rana HL, et al. Improved anti-inflammatory effect of curcumin by designing self-emulsifying drug delivery system. Drug Development and Industrial Pharmacy. 2021;47(9):1432–1438. Available from: https://doi.org/10.1080/03639045.2021.2001486
  4. Kumar M, Tiwari A, Asdaq SMB, Nair AB, Bhatt S, Shinu P, et al. Itraconazole loaded nano-structured lipid carrier for topical ocular delivery: Optimization and evaluation. Saudi Journal of Biological Sciences. 2022;29(1):1–10. Available from: https://doi.org/10.1016/j.sjbs.2021.11.006
  5. Manasa B, Shanmugam DV, Prakash P. Formulation and Evaluation of Itraconazole Proniosomal Gel for Topical Drug Delivery. Acta Scientific Pharmaceutical Sciences. 2022;6(1):18–43. Available from: https://www.actascientific.com/ASPS/pdf/ASPS-06-0831.pdf
  6. Ajjarapu S, Banda S, Basim P, Dudhipala N. Melt Fusion Techniques for Solubility Enhancement: A Comparison of Hot Melt Extrusion and KinetiSol® Technologies. Scientia Pharmaceutica. 2022;90(3):51. Available from: https://doi.org/10.3390/scipharm90030051
  7. Doke VV, Khutle NM, Sharma M, Gupta K. Solubility Enhancement of Poorly Soluble Drug Ezetimibe by Developing Self Nano Emulsifying Drug Delivery System. Indian Journal Of Science And Technology. 2022;15(30):1504–1516. Available from: https://doi.org/10.17485/IJST/v15i30.582
  8. Izham M, Hussin MN, Aziz Y, Yeap MN, Rahman SK, Masarudin HS, et al. Preparation and characterization of self nano-emulsifying drug delivery system loaded with citraland its antiproliferative effect on colorectal cells in vitro. Nanomaterials. 2019;18(7):1028. Available from: https://doi.org/10.3390/nano9071028
  9. Arshad R, Tabish TA, Kiani MH, Ibrahim IM, Shahnaz G, Rahdar A, et al. A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection. Nanomaterials. 2021;11(5):1086. Available from: https://doi.org/10.3390/nano11051086
  10. Syukri Y, Fitriani H, Pandapotan H, Nugroho BH. Formulation, Characterization and Stability of Ibuprofen-Loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS) Indonesian Journal of Pharmacy. 2019;30(2):105. Available from: http://dx.doi.org/10.14499/indonesianjpharm30iss2pp105-113
  11. Buya AB, Ucakar B, Beloqui A, Memvanga PB, Préat V. Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDSs) for senicapoc. International Journal of Pharmaceutics. 2020;580:119180. Available from: https://doi.org/10.1016/j.ijpharm.2020.119180


© 2023 Doke et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Indian Society for Education and Environment (iSee)


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