Serum Tissue Non Specific Alkaline Phosphatase Isoenzyme Level and Severity of Chronic Periodontitis

Gopu Chandran Lenin Perumal; R  Mythili; Senthil Kumar; Subashini Suyambukesan

doi:10.17485/ijst/2014/v7i10.11

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Serum Tissue Non Specific Alkaline Phosphatase Isoenzyme Level and Severity of Chronic Periodontitis

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Indian Journal of Science and Technology

DOI: 10.17485/ijst/2014/v7i10.11

Year: 2014, Volume: 7, Issue: 10, Pages: 1551–1554

Original Article

Serum Tissue Non Specific Alkaline Phosphatase Isoenzyme Level and Severity of Chronic Periodontitis

Gopu Chandran Lenin Perumal^1* , R. Mythili² , Senthil Kumar² , Subashini Suyambukesan3

1 Department of Periodontology, Penang International Dental College, Penang, Malaysia; drgopuchandran@gmail.com
2 Rajah Muthiah Dental College & Hospital, Annamalai University, Chidambaram, Tamilnadu, India
3 Department of Oral medicine & Radiology, Penang International Dental College, Penang, Malaysia

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

The purpose of this study was to estimate and compare the levels of tissue non-specific alkaline phosphatase isoenzyme in serum of healthy individual and in chronic periodontitis patients with varying severity. Serum samples were obtained from 31individuals. 10 from healthy individuals and 21 from chronic periodontitis patients categorized as mild, moderate and severe based on CAL values. The samples were used to determine the Tissue Non – Specific Alkaline Phosphatase Isoenzyme (TNSALP) level. Evaluation and comparison of the tissue non – specific alkaline phosphatase isoenzyme activity between the control and chronic periodontitis patient group showed a decrease in bone type of tissue non – specific alkaline phosphatase level among mild, moderate and severe chronic periodontitis patients group. The steady decrease in Bone type of TNSALP might help to provide useful information if monitored successively over a period of time.

Keywords: Alkaline Phosphatase Isoenzyme, Chronic Periodontitis, Severity of Chronic Periodontitis, Serum Enzymatic Assay, Tissue Non-Specific Alkaline Phosphatase Isoenzyme, TNSALP.