Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine CoCrystal

Engku Nadia Engku Mat Nasir; Fatinah Ab Rahman; Syarifah Abd Rahim; Raihana Zahirah Edros   and Nornizar Anuar  nbsp

doi:10.17485/ijst/2017/v10i7/111216

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Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine CoCrystal

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Indian Journal of Science and Technology

DOI: 10.17485/ijst/2017/v10i7/111216

Year: 2017, Volume: 10, Issue: 7, Pages: 1-5

Original Article

Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine CoCrystal

Engku Nadia Engku Mat Nasir¹ , Fatinah Ab Rahman¹, Syarifah Abd Rahim^1*, Raihana Zahirah Edros² and Nornizar Anuar³

¹Faculty of Chemical and Natural Resources Engineering, Universiti Malaysia Pahang, 26300 Gambang, Pahang, Malaysia; [email protected], [email protected], [email protected] ²Faculty of Engineering Technology, Universiti Malaysia Pahang, 26300 Gambang, Pahang, Malaysia; [email protected] ³Faculty of Chemical Engineering, Universiti Teknologi MARA, Jalan Ilmu 1/1, 40450 Shah Alam, Selangor, Malaysia; [email protected]

*Author for the correspondence:
Syarifah Abd Rahim
Faculty of Chemical and Natural Resources Engineering, Universiti Malaysia Pahang - 26300, Malaysia;
E-mail: [email protected]

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Objectives: Metastable zone width (MSZW) is a crucial parameter in designing co-crystallization process in order to achieve required crystal habits. The effects of operating parameters toward metastable zone width of carbamazepine-saccharin (CBZ-SAC) co-crystal were studied in this research. Methods/Statistical Analysis: Crystallization study was conducted using cooling crystallization method which involves polythermal method. A 250 ml scale size-reactor was used to study the effects of operating parameters on metastable zone width of CBZ-SAC co-crystal which tested with various mol ratio of SAC/CBZ, concentration of CBZ, cooling and heating rates and stirring speeds. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD) and optical microscopy were applied to characterize the CBZ-SAC co-crystals. Findings: The results show that MSZW decreases as the mol ratios of SAC/CBZ increases, whilst also decreases with CBZ concentrations, cooling rates and stirring speeds. Application/Improvements: Cooling crystallization process is extensively used in the manufacture of pharmaceutical drugs.

Keywords: Co-Crystal, Metastable Zone Width, Nucleation Kinetics, Polythermal Method