• P-ISSN 0974-6846 E-ISSN 0974-5645

Indian Journal of Science and Technology


Indian Journal of Science and Technology

Year: 2010, Volume: 3, Issue: 6, Pages: 642-647

Original Article

Clastogenic effect of sodium arsenite in experimental rats and ameliorative effects of antioxidant vitamins C and E


Arsenic, an element ubiquitous in the environment, causes serious health problems in humans. The general population is more exposed to arsenic through drinking water than through air and food. Sodium arsenite, capable of inducing genotoxic effects through oxidative stress, is evaluated for its clastogenic effect by the formation of chromosomal aberrations in the bone marrow cells of Wistar rats. We also investigated whether the oral supplementation of α– tocopherol (400 mg/kg body weight) and ascorbic acid (200 mg/kg body weight) to arsenic–intoxicated rats (100 ppm in drinking water) for 30days, ameliorates arsenic-induced toxicity. We report that the dietary supplementation of antioxidants such as vitamins C and E could prevent sodium arsenite induced toxicity in rats under experimental conditions.
Keywords: Arsenic, genotoxicity, ascorbic acid, α-tocopherol, chromosomal aberrations, vitamins, rat, bone marrow. 


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