Erythropoietin may modify tyrosine kinase activity for its neuroprotective action in mice

M  G  Tyagi

doi:10.17485/ijst/2010/v3i1.24

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Erythropoietin may modify tyrosine kinase activity for its neuroprotective action in mice

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Indian Journal of Science and Technology

DOI: 10.17485/ijst/2010/v3i1.24

Year: 2010, Volume: 3, Issue: 1, Pages: 102-104

Original Article

Erythropoietin may modify tyrosine kinase activity for its neuroprotective action in mice

M. G. Tyagi ^*

Department of Pharmacology,Christian Medical College, Vellore 632002, TN, India
[email protected]

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

The neuroprotective effect of erythropoietin (EpO) was evaluated against MgCl₂ induced cerebral ischemia. EpO (500 IU/kg i.p) prevented the MgCl₂ (0.5M) induced cerebral ischemia in the mice. EpO also reduced the bleeding time in mice by 7.64 %. Pretreatment with tyrosine kinase inhibitor, Genistein (6mg/kg i.p) attenuated the neuroprotective effect of EpO and reversed the effects of EpO on bleeding time in mice. These studies suggest that EpO is protective against MgCl₂ induced cerebral ischemia and a role for tyrosine kinase enzyme in this action is suggested based on the results of this study.
Keywords: Tyrosine kinase, erythropoietin, cerebral ischemia, mice