Indian Journal of Science and Technology
Year: 2010, Volume: 3, Issue: 1, Pages: 102-104
M. G. Tyagi *
Department of Pharmacology,Christian Medical College, Vellore 632002, TN, India
The neuroprotective effect of erythropoietin (EpO) was evaluated against MgCl2 induced cerebral ischemia. EpO (500 IU/kg i.p) prevented the MgCl2 (0.5M) induced cerebral ischemia in the mice. EpO also reduced the bleeding time in mice by 7.64 %. Pretreatment with tyrosine kinase inhibitor, Genistein (6mg/kg i.p) attenuated the neuroprotective effect of EpO and reversed the effects of EpO on bleeding time in mice. These studies suggest that EpO is protective against MgCl2 induced cerebral ischemia and a role for tyrosine kinase enzyme in this action is suggested based on the results of this study.
Keywords: Tyrosine kinase, erythropoietin, cerebral ischemia, mice
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