• P-ISSN 0974-6846 E-ISSN 0974-5645

Indian Journal of Science and Technology


Indian Journal of Science and Technology

Year: 2010, Volume: 3, Issue: 1, Pages: 102-104

Original Article

Erythropoietin may modify tyrosine kinase activity for its neuroprotective action in mice


The neuroprotective effect of erythropoietin (EpO) was evaluated against MgCl2 induced cerebral ischemia. EpO (500 IU/kg i.p) prevented the MgCl2 (0.5M) induced cerebral ischemia in the mice. EpO also reduced the bleeding time in mice by 7.64 %. Pretreatment with tyrosine kinase inhibitor, Genistein (6mg/kg i.p) attenuated the neuroprotective effect of EpO and reversed the effects of EpO on bleeding time in mice. These studies suggest that EpO is protective against MgCl2 induced cerebral ischemia and a role for tyrosine kinase enzyme in this action is suggested based on the results of this study.
Keywords: Tyrosine kinase, erythropoietin, cerebral ischemia, mice 


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