Formulation, Evaluation and Release Kinetics of Low Viscosity Metronidazole Gel with Varying Amount o f Carbopol

Debatri Roy; Sudipta Das; Madhurima Panda; Sabnam Sultana; Mrittika Mandal; Ishita Sil; Baban Majumder

doi:10.17485/IJST/v15i48.2145

Article

Formulation, Evaluation and Release Kinetics of Low Viscosity Metronidazole Gel with Varying Amount o f Carbopol

VIEWS 902
PDF 146

Indian Journal of Science and Technology

DOI: 10.17485/IJST/v15i48.2145

Year: 2022, Volume: 15, Issue: 48, Pages: 2690-2698

Original Article

Formulation, Evaluation and Release Kinetics of Low Viscosity Metronidazole Gel with Varying Amount o f Carbopol

Debatri Roy¹, Sudipta Das^1*, Madhurima Panda¹, Sabnam Sultana¹, Mrittika Mandal¹, Ishita Sil¹, Baban Majumder¹

¹Department of Pharmaceutics, Netaji Subhas Chandra Bose Institute of Pharmacy, Nadia, 741222, West Bengal, India

*Corresponding Author
Email: [email protected]

Received Date:06 November 2022, Accepted Date:28 November 2022, Published Date:24 December 2022

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Objective: The study is centered on formulation and evaluation of low viscosity metronidazole gel with varying amount of Carbopol. Methods: Formulations (F1, F2 and F3) of Metronidazole in gel form were done in varying amounts of Carbopol. Prepared gels were inspected for surface pH, viscosity, spreadability, antimicrobial susceptibility, drug content percentage, in vitro process of drug release, release kinetics and stability testing. Findings: Formulation pH was placed in between 5 and 6. Measured viscosity of F3 was 34.16 Pa.sec for high-rise amount of Carbopol and for F2 & F1 it was 33.43 Pa.sec and 30.44 Pa.sec respectively. Highest spreadability was achieved for F1 which was 9.72 gm.cm/sec and for F2 and F3 it was 7.3 gm.cm/sec & 6.62 gm.cm/sec. Release study for drug (In vitro) report for F1, F2, and F3 was 91.945 %, 89.612 % and 88.598 % respectively for 120 minutes study. Drug release kinetics was scrutinized by First Order model, Zero Order model, Higuchi model, Hixon- Crowell model and Korsmeyers-Peppas model. Novelty: This study formulates low viscosity gel of metronidazole using polymer Carbopol. The viscosity of gel formulation can alter drug release pattern and spreadability in better way. Study was focused on improvement of spreadability which is linked with easy absorption in to the application area. Low viscosity aqueous gel can spread easily.

Keywords: Periodontal Disease; Metronidazole; Carbopol; In Vitro Type Drug Release; Kinetics For Drug Release

References

Mahmood AA, Abdul-Wahab GA, Al-Karawi SI. Effect of hyaluronan and metronidazole gels in management of chronic periodontitis. Journal of International Oral Health. 2019;11(3):158. Available from: https://doi.org/10.4103/jioh.jioh_292_18
Fanas SA, Brigi C, Varma SR, Desai V, Senok A, D, et al. The prevalence of novel periodontal pathogens and bacterial complexes in Stage II generalized periodontitis based on 16S rRNA next generation sequencing. Journal of Applied Oral Science. 2021;29:1–16. Available from: https://doi.org/10.1590%2F1678-7757-2020-0787
Kumar G, Chaudhary K, Mogha NK, Kant A, Masram DT. Extended Release of Metronidazole Drug Using Chitosan/Graphene Oxide Bionanocomposite Beads as the Drug Carrier. ACS Omega. 2021;6(31):20433–20444. Available from: https://doi.org/10.1021/acsomega.1c02422
Ceruelos AH, Romero-Quezada LC, Ledezma R, Contreras JC, L. Therapeutic uses of metronidazole and its side effects: an update. European Review for Medical and Pharmacological Sciences. 2019;23(1):397–401. Available from: https://doi.org/10.26355/eurrev_201901_16788
Becker ML, Uden RCAEV, Giezen TJ, Meijer K, Houtenbos I, Bemt PMLAVD. Drug-drug interactions with metronidazole and itraconazole in patients using acenocoumarol. European Journal of Clinical Pharmacology. 2020;76(10):1457–1464. Available from: https://doi.org/10.1007/s00228-020-02930-z
Safitri FI, Nawangsari D, Febrina D. Overview: Application of Carbopol 940 in Gel. Proceedings of the International Conference on Health and Medical Sciences (AHMS 2020). 2021;13:80–84. Available from: https://dx.doi.org/10.2991/ahsr.k.210127.018
Syed MA, Hanif S, Ain NU, Syed HK, Zahoor AF, Khan IU, et al. Assessment of Binary Agarose–Carbopol Buccal Gels for Mucoadhesive Drug Delivery: Ex Vivo and In Vivo Characterization. Molecules. 2022;27(20):7004. Available from: https://doi.org/10.3390/molecules27207004
Dawood NM, Jassim Z, Ghareeb M. Studying the Effect of Different Gelling Agent on the Preparation and Characterization of Metronidazole as Topical Emulgel. Asian Journal of Pharmaceutical and Clinical Research. 2019;12(3):571–577. Available from: https://www.researchgate.net/publication/331959492
Naseem F, Shah SU, Rashid SA, Farid A, Almehmadi M, Alghamdi S. Metronidazole Based Floating Bioadhesive Drug Delivery System for Potential Eradication of H. pylori: Preparation and In Vitro Characterization. Polymers. 2022;14(3):519. Available from: https://pubmed.ncbi.nlm.nih.gov/35160508/
Hulme-Smith CN, Hari V, Mellin P. Spreadability Testing of Powder for Additive Manufacturing. BHM Berg- und Hüttenmännische Monatshefte. 2021;166(1):9–13. Available from: https://doi.org/10.1007/s00501-020-01069-9
Mehta J, Shah C, Upadhyay. Formulation and Development of Luliconazole loaded Microemulgel using QBD Approach. International Journal of Pharmaceutical Research and Applications. 2021;6(3):209–221. Available from: https://ijprajournal.com/issue_dcp/Formulation%20and%20Development%20of%20Luliconazole%20loaded%20Microemulgel%20using%20QBD%20Approach.pdf
Das S, Samanta A, Mondal S, Roy D, Nayak AK. Design and release kinetics of liposomes containing abiraterone acetate for treatment of prostate cancer. Sensors International. 2021;2:100077. Available from: https://doi.org/10.1016/j.sintl.2020.100077
Aragon N, Jaramillo-Echeverry A, Ramirez-Malule H. Bibliometric analysis of bacterial resistance on periodontal disease. Journal of Applied Pharmaceutical Science. 2021;11(04):118–124. Available from: https://doi.org/10.7324/JAPS.2021.110414-1
Singh VK, Anis A, Banerjee I, Pramanik K, Bhattacharya MK, Pal K. Preparation and characterization of novel carbopol based bigels for topical delivery of metronidazole for the treatment of bacterial vaginosis. Materials Science and Engineering. 2014;44:151–158. Available from: https://doi.org/10.1016/j.msec.2014.08.026
Wróblewska M, Szymańska E, Szekalska M, Winnicka K. Different Types of Gel Carriers as Metronidazole Delivery Systems to the Oral Mucosa. Polymers. 2020;12(3):680. Available from: https://doi.org/10.3390/polym12030680
Roy D, Das S, Samanta A. Design and In vitro release kinetics of liposomal formulation of Acyclovir. International Journal of Applied Pharmaceutics. 2019;11(6):61–65. Available from: https://doi.org/10.22159/ijap.2019v11i6.34917
Herold SE. Release kinetics of metronidazole from 3D printed silicone scaffolds. University of Louisville. 2022. Available from: https://doi.org/10.18297/etd/3921
Das S, Samanta A, Bankura K, Roy D, Nayak AK. Fabrication and Release Kinetics of Liposomes Containing Leuprolide Acetate. Journal of Basic and Applied Research in Biomedicine. 2021;7(1):35–38. Available from: https://jbarbiomed.com/index.php/home/article/view/13/11

Copyright

© 2022 Roy et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Published By Indian Society for Education and Environment (iSee)