Mild antihyperglycaemic activity in Eclipta alba, Berberis aristata, Betula utilis, Cedrus deodara, Myristica fragrans and Terminalia chebula

Rehan Ahmad; Swayam Prakash Srivastava; Rakesh Maurya; S M  Rajendran; K R  Arya  and Arvind K  Srivastava    nbsp

doi:10.17485/ijst/2008/v1i5.1

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Mild antihyperglycaemic activity in Eclipta alba, Berberis aristata, Betula utilis, Cedrus deodara, Myristica fragrans and Terminalia chebula

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Indian Journal of Science and Technology

DOI: 10.17485/ijst/2008/v1i5.1

Year: 2008, Volume: 1, Issue: 5, Pages: 1-6

Original Article

Mild antihyperglycaemic activity in Eclipta alba, Berberis aristata, Betula utilis, Cedrus deodara, Myristica fragrans and Terminalia chebula

Rehan Ahmad¹ , Swayam Prakash Srivastava¹ , Rakesh Maurya², S.M. Rajendran³ , K.R. Arya³ and Arvind K. Srivastava^{1 *}

1Divisions of Biochemistry,
2Medicinal Chemistry and
3Botany, Central Drug Research Institute, Lucknow-226001,India.

*Author for the correspondence:
Arvind K. Srivastava
Divisions of Biochemistry
Central Drug Research Institute, Lucknow-226001,India.
E-mail: [email protected]

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

The ethanolic extracts of different parts of the following plants viz. Eclipta alba Hassk (Asteraceae) whole plant, roots of Berberis aristata DC (Berbidaceae), stem wood of Betula utilis D. Don (Betulaceae), stem wood of Cedrus deodara (Pinaceae), and fruits of Myristica fragrans Houtt. (Myristcaceae) exhibited 7.5, 8.3, 9.2, 6.0, and 8.7% significant fall in blood glucose profile in a single dose experiment on Streptozotocin-induced diabetic rats. In single dose experiment nearly 8.0% decline in blood glucose profile of Streptozotocininduced diabetic rats was observed with a known antidiabetic ethanolic extract of the fruits of Terminalia chebula (Gaertn.) Retz. (Combretaceae).

Key Words: Antidiabetic plants, antihyperglycaemic activity, streptozotocin, diabetes, animal models.